Current Status and Perspective Biomarkers in AFP Negative HCC: Towards Screening for and Diagnosing Hepatocellular Carcinoma at an Earlier Stage

  • Ping Luo
  • Sanyun Wu
  • Yalan Yu
  • Xinliang Ming
  • Shuo Li
  • Xuelan Zuo
  • Jiancheng TuEmail author


Hepatocellular carcinoma (HCC) is one of the most malignant cancer with high morbidity and mortality which lead to a serious burden to society. AFP (alpha-fetoprotein) is the most widely used serum biomarker to detect HCC worldwide. However, no AFP elevation have been found in many HCC and AFP analysis can’t be used to screen HCC in these cases. Currently, many studies have been carried out to find reliable biomarker in diagnosing AFP-negative HCC. Such biomarker would help the diagnosis of AFP-negative HCC, ensuring the timely initiation of treatment. In this review, we highlight the important role of biomarkers that can differentiate AFP-negative HCCs, and discuss their potential clinical applications as biomarkers for the diagnosis of AFP-negative HCC.


HCC Biomarker AFP-negative Diagnose 



This work was supported by the National Basic Research Program of China (973 Program) (2012CB720605).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that there are no conflicts of interest.


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Copyright information

© Arányi Lajos Foundation 2019

Authors and Affiliations

  • Ping Luo
    • 1
    • 2
  • Sanyun Wu
    • 2
  • Yalan Yu
    • 2
  • Xinliang Ming
    • 1
  • Shuo Li
    • 1
  • Xuelan Zuo
    • 2
  • Jiancheng Tu
    • 1
    Email author
  1. 1.Department of Clinical Laboratory Medicine & Center for Gene DiagnosisZhongnan Hospital of Wuhan UniversityWuhanChina
  2. 2.Department of HematologyZhongnan Hospital of Wuhan UniversityWuhanChina

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