The Role of Log Odds of Positive Lymph Nodes in Predicting the Survival after Resection for Ampullary Adenocarcinoma

  • Cihan AgalarEmail author
  • Anıl Aysal
  • Tarkan Unek
  • Tufan Egeli
  • Mucahit Ozbilgin
  • Nesrin Akturk
  • Huseyin Salih Semiz
  • Tugba Unek
  • Mesut Akarsu
  • Müjde Soyturk
  • Hulya Ellidokuz
  • Ozgul Sagol
  • Ibrahim Astarcioglu
Original Article


Lymph node metastasis is a important factor on survival in ampullary adenocarcinoma. Log odds of positive lymph nodes (LODDS) is a novel prognostic indicator on lymph node status. We aimed to evaluate the prognostic impact of LODDS for the patients with ampullary adenocarcinoma who underwent R0 pancreaticoduodenectomy. The study includes 42 patients.. LODDS was calculated as “log (number of metastatic lymph nodes+0.5)/(number of total harvested nodes - metastatic lymph nodes+0.5)”. LODDS subgroups were created based on their LODDS value: LODDS1(LODDS≤ − 1.5), LODDS2(−1.5 < LODDS≤ − 1.0), LODDS3(−1.0 < LODDS≤ − 0.5), LODDS4(LODDS> − 0.5). The mean survival time was 72.7 ± 7.82 months. Survival rates for 1, 3 and 5 years were 93%, 65% and 45%, respectively. The mean LODDS value was −1.0466 ± 0.51. LODDS subgroups show strong correlation with Overall Survival(OS). The mean survival were 114.8, 81.8, 56.6 and 25.6 months in LODDS subgroups 1, 2, 3 and 4, respectively (Log-rank; p = 0.002), in addition LOODS values shows correlation with perineural invasion and micro vascular invasion (p = 0.015 and p = 0.001 respectively). Findings in our patient group support the hypothesis that LODDS subgroups correlate with OS, and that value of LODDS has considerable role in prediction of OS as well.


Log odds of positive lymph nodes Ampullary adenocarcinoma LODDS Microvascular invasion Perineural invasion 


Compliance with Ethical Standards

Conflict of Interest

All authors declare that there is no potential and real conflict of interest.


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Copyright information

© Arányi Lajos Foundation 2019

Authors and Affiliations

  • Cihan Agalar
    • 1
    Email author
  • Anıl Aysal
    • 2
  • Tarkan Unek
    • 1
  • Tufan Egeli
    • 1
  • Mucahit Ozbilgin
    • 1
  • Nesrin Akturk
    • 3
  • Huseyin Salih Semiz
    • 4
  • Tugba Unek
    • 4
  • Mesut Akarsu
    • 5
  • Müjde Soyturk
    • 5
  • Hulya Ellidokuz
    • 6
  • Ozgul Sagol
    • 2
  • Ibrahim Astarcioglu
    • 1
  1. 1.The Department of General SurgeryDokuz Eylul University School of MedicineİzmirTurkey
  2. 2.The Department of PathologyDokuz Eylul University School of MedicineIzmirTurkey
  3. 3.The Department of Radiation OncologyDokuz Eylul University School of MedicineIzmirTurkey
  4. 4.The Department of Medical OncologyDokuz Eylul University School of MedicineIzmirTurkey
  5. 5.The Department of GastroenterologyDokuz Eylul University School of MedicineIzmirTurkey
  6. 6.The Department of Preventive OncologyDokuz Eylul University School of MedicineIzmirTurkey

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