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Systems Oncology: Bridging Pancreatic and Castrate Resistant Prostate Cancer

  • A. Fucic
  • A. Aghajanyan
  • Z. Culig
  • N. Le Novere
Review
First Online:
Received:
Accepted:

Abstract

Large investments by pharmaceutical companies in the development of new antineoplastic drugs have not been resulting in adequate advances of new therapies. Despite the introduction of new methods, technologies, translational medicine and bioinformatics, the usage of collected knowledge is unsatisfactory. In this paper, using examples of pancreatic ductal adenocarcinoma (PaC) and castrate-resistant prostate cancer (CRPC), we proposed a concept showing that, in order to improve applicability of current knowledge in oncology, the re-clustering of clinical and scientific data is crucial. Such an approach, based on systems oncology, would include bridging of data on biomarkers and pathways between different cancer types. Proposed concept would introduce a new matrix, which enables combining of already approved therapies between cancer types. Paper provides a (a) detailed analysis of similarities in mechanisms of etiology and progression between PaC and CRPC, (b) diabetes as common hallmark of both cancer types and (c) knowledge gaps and directions of future investigations. Proposed horizontal and vertical matrix in cancer profiling has potency to improve current antineoplastic therapy efficacy. Systems biology map using Systems Biology Graphical Notation Language is used for summarizing complex interactions and similarities of mechanisms in biology of PaC and CRPC.

Keywords

Pancreatic cancer Castrate resistant prostate cancer Cancer marker Systems oncology Cancer profiling 
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Notes

Acknowledgements

Study was funded by institutional funds of Institute for Medical Research and Occupational Health through Croatian Ministry of Science and Education.

Compliance with Ethical Standards

Conflict of Interest

Authors declare no conflict of interest.

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© Arányi Lajos Foundation 2018

Authors and Affiliations

  • A. Fucic
    • 1
  • A. Aghajanyan
    • 2
  • Z. Culig
    • 3
  • N. Le Novere
    • 4
  1. 1.Institute for Medical Research and Occupational HealthZagrebCroatia
  2. 2.Institute of MedicinePeoples’ Friendship University of RussiaMoscowRussian Federation
  3. 3.Department of UrologyMedical University of InnsbruckInnsbruckAustria
  4. 4.Babraham InstituteCambridgeUK

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