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Pathology & Oncology Research

, Volume 25, Issue 2, pp 811–814 | Cite as

Genetic Analysis of Brazilian Patients with Gallbladder Cancer

  • Cristina Sábato
  • Luciana Bastos-Rodrigues
  • Debora Chaves Moraes
  • Eitan Friedman
  • Luiz De MarcoEmail author
  • Vivian Resende
Letter to the Editor
  • 53 Downloads

To the Editor,

Gallbladder cancer (GBC) is a rare neoplasm with poor prognosis and overall survival [1]. Its underlying molecular pathogenesis remains largely elusive and the accumulation of multiple somatic genetic alterations as well as chronic inflammation associated with gallstone formation promotes epithelial dysplasia and progression to adenocarcinoma postulated [2, 3, 4].

It has been shown that some indigenous people and ethnic groups have higher incidence and mortality rates, with differences within the same country and some populations identified as high-risk groups for GBC development. The highest incidence rates are found in populations living west of the Andes, northern India and populations of American and Mexican Indians [1].

The potential association in genetically heterogeneous Brazilian GBC patients has not been previously reported. Based in a comprehensive study [4] and COSMIC database (http://cancer.sanger.ac.uk/cosmic) we investigated the contribution of TP53, KRAS,...

Notes

Acknowledgements

This work was partially funded by grants from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq # 405053/2013-4) and Fundação de Amparo a Pesquisa de Minas Gerais (FAPEMIG # APQ-00220-14).

Compliance with Ethical Standards

This work was approved by the University Ethics Committee (CAAE-09135912.6.0000.5149).

Disclosure Statement

Nothing to disclose.

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Copyright information

© Arányi Lajos Foundation 2018

Authors and Affiliations

  • Cristina Sábato
    • 1
  • Luciana Bastos-Rodrigues
    • 2
  • Debora Chaves Moraes
    • 1
  • Eitan Friedman
    • 3
    • 4
  • Luiz De Marco
    • 1
    Email author
  • Vivian Resende
    • 1
  1. 1.Department of SurgeryUniversidade Federal de Minas GeraisBelo HorizonteBrazil
  2. 2.Department of NutritionUniversidade Federal de Minas GeraisBelo HorizonteBrazil
  3. 3.The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical CenterTel-HashomerIsrael
  4. 4.Sackler School of MedicineTel-Aviv UniversityTel-AvivIsrael

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