Relationship Between -2028 C/T SELP Gene Polymorphism, Concentration of Plasma P-Selectin and Risk of Malnutrition in Head and Neck Cancer Patients
- 104 Downloads
Until today there is a lack of molecular factors, that could predict either cancer malnutrition or cachexia. Among potential mechanisms, that contribute to development of above syndromes, the systemic inflammatory response with overproduction of cytokines and adhesion molecules is the most likely. Recent papers suggested crucial role of P-selectin adhesion molecule in the initiation of leukocytes recruitment to the site of injury during inflammation, promotion of tumor aggressiveness and contribution to cancer cachexia. The aim of the study was to investigate SELP -2028 C/T polymorphism as a risk factor of malnutrition in 66 head and neck cancer (HNC) patients subjected to radiotherapy. Genotyping was conducted by real-time PCR method by means of TaqMan SNP Genotyping Assay. P-selectin Human ELISA Kit was used to determine P-selectin concentration in each extracted plasma samples. CC homozygous subjects had 4-fold higher risk score of being qualified as severely malnourished compared to other genotype carriers (p = 0.015). However, the TT homozygous patients were at lowest risk of severe weight loss >10% during the therapy period (OR = 0.20; p = 0.019). We also noted, that CC genotype carriers had significantly higher risk of early death incidence compared to CT or TT genotype (median survival time: 29 vs 34 months; HR = 3.02; p = 0.0085). Studied SELP -2028 C/T seems to be a novel attractive predictive factor of cancer malnutrition in HNC patients, perhaps in a future, patients carrying unfavorable CC genotype could be earlier scheduled for pharmaceutical intervention with parenterall nutrition, therefore they could be prevented from the development of severe malnutrition or even cachexia.
KeywordsMalnutrition Cachexia Head and neck cancer SELP P-selectin
Compliance with Ethical Standards
Conflict of Interest
The authors declare no conflict of interest.
This study was not financially supported or funded.
- 10.Reiner AP, Carlson CS, Thyagarajan B, Rieder MJ, Polak JF, Siscovick DS, Nickerson DA, Jacobs DR Jr, Gross MD (2008) Soluble P-selectin, SELP polymorphisms, and atherosclerotic risk in European-American and African-African young adults: the coronary artery risk development in young adults (CARDIA) study. Send to Arterioscler Thromb Vasc Biol 28(8):1549–1555CrossRefGoogle Scholar
- 11.Burkhardt J, Blume M, Petit-Teixeira E, Hugo Teixeira V, Steiner A, Quente E, Wolfram G, Scholz M, Pierlot C, Migliorini P, Bombardieri S, Balsa A, Westhovens R, Barrera P, Radstake TRDJ, Alves H, Bardin T, Prum B, Emmrich F, Cornelis F, Ahnert P, Kirsten H (2014) Cellular adhesion gene SELP is associated with rheumatoid arthritis and displays differential allelic expression. PLoS One 9(8):e103872CrossRefGoogle Scholar
- 15.Volcik KA, Ballantyne CM, Coresh J, Folsom AR, Boerwinkle E (2007) Specific P-selectin and P-selectin glycoprotein ligand–1 genotypes/haplotypes are associated with risk of incident CHD and ischemic stroke: the atherosclerosis risk in communities (ARIC) study. Atherosclerosis 195:e76–e82CrossRefGoogle Scholar
- 16.Jacobin VM, Deramchia K, Mornet S et al (2011) MRI of inducible P-selectin expression in human activated platelets involved in the early stages of atherosclerosis. NMR Biomed 24:413–424Google Scholar
- 18.Volcik KA, Ballantyne CM, Coresh J, Folsom AR, Wu KK, Boerwinkle E (2006) P-selectin Thr715Pro polymorphism predicts P-selectin levels but not risk of incident coronary heart disease or ischemic stroke in a cohort of 14595 participants: the atherosclerosis risk in communities study. Atherosclerosis 186:74–79CrossRefGoogle Scholar
- 19.Kou L, Yang N, Chen G et al (2016) Association of SELP genetic polymorphisms and additional gene-smoking interaction on cardiovascular disease in Chinese Han population. Int J Clin Exp Pathol 9(9):9612–9618Google Scholar