Human Papillomavirus Detection Strategies in Retinoblastoma
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Epidemiological and molecular evidence has demonstrated human papillomavirus (HPV) to be the aetiological agent of both benign (warts, papillomas) and malignant tumors (anogenital and cervical carcinomas). Retinoblastoma (RB) is the most frequent childhood intraocular malignant tumour, with an incidence of 1 of 18,000–30,000 live births. Increased incidence of sporadic RB is seen in areas of low socioeconomic status (South America, Africa and Asia), raising the possibility of infection as a risk factor in its development. The development of retinoblastoma occurs as a result of the absence or inactivation of pRb protein. Earlier studies have also suggested an association of HPV with sporadic retinoblastoma, indicating that the virus may have a role in the development of these tumors [1, 2] It has been reported that vertical transmission of HPV from mothers to infants may occur through an infected birth canal. HPV DNA has also been detected in the placenta and amniotic fluid...
SC: Perform all experimental work, data collection, analysis, interpretation and writing. SS,NS AS,: Conception and design. BC,SK,: Acquisition of clinical data.
This study was financially supported by research grant from Indian Council of Medical Research, New Delhi.
Compliance with Ethical Standards
Conflict of Interest
This study was conducted after approval from the Institute Ethics Committee, AIIMS, New Delhi and carried out in accordance with Declaration of Helsinki principles. Informed consent was obtained from all patients participating in this study.
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