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Stanniocalcin-2 May Be a Potentially Valuable Prognostic Marker in Endometrial Cancer: a Preliminary Study

  • Hulya Ayik AydinEmail author
  • Tayfun Toptas
  • Selen Bozkurt
  • Armagan Aydin
  • Gulgun Erdogan
  • Elif Pestereli
  • Tayup Simsek
Original Article
  • 30 Downloads

Abstract

In the current study, we primarily aimed to investigate stanniocalcin-2 (STC2) protein expression pattern in hysterectomy specimens from patients with endometrioid type endometrial cancer (EC) using immunohistochemistry. Secondly, in order to clarify its prognostic impact, we examined relationships of the expression levels of STC2 with clinicopathologic features and outcome of patients. Histopathology slides of 49 patients were stained with the monoclonal mouse antibody targeting STC2 protein. The expression levels of STC2 were classified based on three-tiered semiquantitative scheme: negative expression, expression level of 0; low-expression, expression level of 1+; and high-expression, expression levels of 2+ and 3+. Recurrence-free survival (RFS) was used as the primary prognostic outcome. Immunohistochemical analysis revealed that 73.5% of tissue samples exhibited positive staining with STC2. The intensity of staining with STC2 was weak in 40.8%, moderate in 22.4%, and strong in 10.2%. Thirty-eight percent of samples showed negative expression; 18.4%, low-expression (1+); and 42.8%, high-expression (2 to 3+). High-expression of STC2 was significantly associated with grade 2–3 tumors (p = 0.026) and disease recurrence (p = 0.013). Multivariate analysis revealed that both the tumor grade and STC2 were independent predictors of disease recurrence. Kaplan-Meier analyses confirmed that patients with high-expression of STC2 had a significantly poorer RFS than those with negative or low STC2 expression (p = 0.037); although overall survival did not differ with respect to expression levels of STC2 (p = 0.148). In conclusion, high-expression of STC2 is a negative prognostic factor, associated with increased risk of recurrence in endometrioid EC.

Keywords

Stanniocalcin-2 Endometrial cancer Prognostic factor Recurrence 

Notes

Acknowledgments

The authors received no financial support for the research, authorship, and/or publication of this article.

Compliance with Ethical Standards

Conflicts of Interest

The authors declare no conflicts of interest.

Ethical Approval

All procedures performed involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study has been approved by Ethics Committee of the Akdeniz University School of Medicine. A written informed consent is not required for this type of retrospective study.

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Copyright information

© Arányi Lajos Foundation 2019

Authors and Affiliations

  1. 1.Department of Gynecologic OncologyAkdeniz University School of MedicineAntalyaTurkey
  2. 2.Department of Gynecologic OncologyAntalya Research and Training HospitalAntalyaTurkey
  3. 3.Department of Biostatistics and Medical InformaticsAkdeniz University School of MedicineAntalyaTurkey
  4. 4.Department of Medical OncologyAntalya Research and Training HospitalAntalyaTurkey
  5. 5.Department of Gyneco-pathologyAkdeniz University School of MedicineAntalyaTurkey

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