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Pathology & Oncology Research

, Volume 25, Issue 1, pp 89–95 | Cite as

Long Non-Coding RNA SPRY4-IT1 Can Predict Poor Prognosis in Digestive System Malignancies: a Meta-Analysis

  • Cheng Sun
  • Yangyang Ding
  • Shimin Wang
  • Wei HuEmail author
Original Article

Abstract

Recent studies have reported that long non-coding RNA SPRY4 intron transcript 1 (SPRY4-IT1) is abnormally expressed in malignant digestive tumors and associated with prognosis. But its clinical relevance is unclear. Here, we performed a meta-analysis aims to evaluate the prognostic value of SPRY4-IT1 in digestive system malignancies. We systematic search the PubMed, Web of Science, ScienceDirect and Wiley Online Library database to eligible studies. The pooled hazard ratios (HRs) with a 95% confidence interval (95% CI) were calculated to explored the association of lncRNA SPRY4-IT1 with prognosis. Five studies were eligible for analysis, a total of 518 patients were included. Meta-analysis indicated that overexpression of SPRY4-IT1 was associated with poor over survival (OS) (HR = 1.24, 95%CI:0.49–1.98; random-effects model). The clinicopathological parameters analysis further showed that increased expression level of SPRY4-IT1 was positively correlated with lymph node metastasis (HR = 1.45, 95% CI =0.88–2.02; fixed-effects model), TNM stage (HR = 1.24,95% CI = 0.78–1.70; fixed-effects model), and invasion depth (HR = 1.25,95% CI = 0.63–1.88; fixed-effects model). lncRNA SPRY4-IT1 may serve as a potential prognostic marker in malignant digestive tumors.

Keywords

lncRNA SPRY4-IT1 Prognosis Metastasis Meta-analysis 

Abbreviations

HR

hazard ratios

CI

confidence interval

OS

overall survival

CRC

colorectal cancer

GC

gastric cancer

ESCC

esophageal squamous

Notes

Acknowledgements

This work was partly supported by This work was supported by the Natural Science Foundation of Anhui Province (9101051201).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that there is no conflict of interests regarding the publication of this paper.

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Copyright information

© Arányi Lajos Foundation 2017

Authors and Affiliations

  1. 1.Department of PharmacologyThe Second Hospital of Anhui Medical UniversityHefeiPeople’s Republic of China
  2. 2.Department of Hematology/Hematological LabThe Second Hospital of Anhui Medical UniversityHefeiPeople’s Republic of China

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