Novel Recombinant Seneca Valley Virus Isolated from Slaughtered Pigs in Guangdong Province
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Since the first outbreak in Brazil in 2015, Seneca Valley virus (SVV) associated with porcine idiopathic vesicular disease, has shown increasing geographic distribution. Cases of SVV have been reported from several countries including the United States (US), Colombia, Thailand, Canada, and China (Pasma et al.2008; Zhang et al.2015; Sun et al.2017; Wu et al.2017; Liu et al.2018; Saeng-Chuto et al.2018). SVV was first identified in the US in 2002 and is the only member of the genus Senecavirus in the family Picornaviridae (Hales et al.2008; Leme et al.2017). The SVV genome contains a large open reading frame (ORF) encoding a polyprotein, which is cleaved into various mature viral proteins including the leader protein (L), structural proteins (VP1, VP2, VP3, and VP4), and non-structural proteins (2A, 2B, 2C, 3A, 3B, 3C, and 3D) (Hales et al.2008). Structural proteins bind to their receptor, anthrax toxin receptor 1, to mediate viral invasion and stimulate specific immunity...
This work was supported by the Key Research and Development Program of Guangdong Province (2019B020218004).
Compliance with Ethical Standards
Conflict of interest
The authors declare that they have no conflict of interest.
Animal and Human Rights Statement
All institutional and national guidelines for the care and use of animals were followed.
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