Establishment of Novel Monoclonal Fabs Specific for Epstein-Barr Virus Encoded Latent Membrane Protein 1
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Epstein-Barr virus (EBV, also termed human herpesvirus-4) was the first identified human tumor virus. Since its discovery in 1964, studies have shown that EBV infects over 90% of all people by the time they are adults (Williams and Crawford 2006). EBV infection can result in mucocutaneous and systemic diseases, ranging from self-limited illnesses to aggressive malignancies, including B cell Hodgkin lymphoma and nasopharyngeal carcinoma. In vitro, EBV transforms resting B cells into proliferating blast cells (Pope et al. 1968). This transformation depends on the expression of nine viral latent proteins, including latent membrane protein 1 (LMP1). LMP1 expression in B lymphocytes can constitutively result in lymphoma. EBV-positive tumors express LMP1 on their surface (Deacon et al. 1993). These findings have implicated LMP1 as a suitable target for immunotherapy to treat EBV related Hodgkin lymphoma and nasopharyngeal carcinoma.
LMP1 is a membrane protein composed of a...
This work was supported by the National Natural Science Foundation of China (Grant Numbers: 81402542 and 81772166) and the scholarship of Pujiang Talents in Shanghai to Fang Wei (Grant Number: 14PJ1405600).
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Conflict of interest
The authors declare that they have no conflict of interest.
Animal and Human Rights Statement
This article does not contain any studies with human or animal subjects performed by any of the authors.
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