Virologica Sinica

, Volume 34, Issue 1, pp 97–101 | Cite as

Low Pathogenic Avian Influenza A (H5N7) Virus Isolated from a Domestic Duck in Dongting Lake Wetland of China, 2016

  • Liping Ma
  • Haizhou Liu
  • Runkun Wang
  • Tao Jin
  • Di Liu
  • George Fu Gao
  • Quanjiao ChenEmail author

Dear Editor,

The avian influenza virus (AIV) H5N7 was first isolated from wild birds in North America in 2001 (Spackman et al. 2007), and information on only 25 strains of this virus has been deposited in the Global Initiative on Sharing All Influenza Data (GISAID- database until October 30, 2018. Twenty viruses were identified in the United States from 2001 to 2017, three viruses in Denmark in 2003, and two viruses in Mongolia in 2014 (GISAID- All these H5N7 viruses were low pathogenicity and were discovered in wild migratory birds.

Wild migratory birds serve as natural reservoir of AIVs and disseminate the viruses during long-distance migration. Wetlands are important for wild migratory birds as stopover for resting and breeding. In China, millions of domestic ducks are also raised near Dongting Lake Wetland Nature Reverse (Hunan Province Rural Social and Economic Investigation Team 2008)...



This work was funded by the National Science and Technology Major Project (2018ZX10101004), the Open Research Fund Program of Wuhan National Bio-Safety Level 4 Lab of CAS (NBL2017003), China Ministry of Science and Technology (MOST) Key Research and Development Program (2016YFC1200800), and the Shenzhen Science and Technology Research and Development Project (JCYJ20151029151932602). The funding sources had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Animal and Human Rights Statement

This article does not contain any studies with human subjects performed by any of the authors. All studies involving animals were conducted according to the animal welfare guidelines of the World Organisation for Animal Health.

Supplementary material

12250_2018_81_MOESM1_ESM.pdf (5.9 mb)
Supplementary material 1 (PDF 6056 kb)


  1. Abdel-Ghafar AN, Chotpitayasunondh T, Gao Z, Hayden FG, Nguyen DH, de Jong MD, Naghdaliyev A, Peiris JS, Shindo N, Soeroso S, Uyeki TM (2008) Writing Committee of the Second World Health Organization Consultation on Clinical aspects of human infection with avian influenza A(H5N1) virus. Update on avian influenza A (H5N1) virus infection in humans. N Engl J Med 358:261–273CrossRefPubMedGoogle Scholar
  2. Adlhoch C, Brown IH, Angelova SG, Bálint Á, Bouwstra R, Buda S, Castrucci MR, Dabrera G, Dán Á, Grund C, et al (2016) Highly pathogenic avian influenza A(H5N8) outbreaks: protection and management of exposed people in Europe, 2014/15 and 2016. Euro Surveill 21:30419CrossRefPubMedPubMedCentralGoogle Scholar
  3. Data available from global initiative on sharing all influenza data, GISAID. Accessed 30 June 2017
  4. Duan L, Campitelli L, Fan XH, Leung YH, Vijaykrishna D, Zhang JX, Donatelli I, Delogu M, Li KS, Foni E, et al (2007) Characterization of low-pathogenic H5 subtype influenza viruses from Eurasia: implications for the origin of highly pathogenic H5N1 viruses. J Virol 81:7529–7539CrossRefPubMedPubMedCentralGoogle Scholar
  5. Hunan Province Rural Social and Economic Investigation Team (2008) Rural statistical yearbook of Hunan 205 ppGoogle Scholar
  6. Kuchipudi SV, Tellabati M, Sebastian S, Londt BZ, Jansen C, Vervelde L, Brookes SM, Brown IH, Dunham SP, Chang KC (2014) Highly pathogenic avian influenza virus infection in chickens but not ducks is associated with elevated host immune and pro-inflammatory responses. Vet Res 45:118CrossRefPubMedPubMedCentralGoogle Scholar
  7. Li KS, Guan Y, Wang J, Smith GJ, Xu KM, Duan L, Rahardjo AP, Puthavathana P, Buranathai C, Nguyen TD, et al (2004) Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia. Nature 430:209–213CrossRefPubMedGoogle Scholar
  8. Li M, Liu H, Bi Y, Sun J, Wong G, Liu D, Li L, Liu J, Chen Q, Wang H, He Y, Shi W, Gao GF, Chen J (2017) Highly pathogenic avian influenza A (H5N8) virus in wild migratory birds, Qinghai Lake, China. Emerg Infect Dis 23:637–641CrossRefPubMedPubMedCentralGoogle Scholar
  9. Liu D, Shi W, Shi Y, Wang D, Xiao H, Li W, Bi Y, Wu Y, Li X, Yan J, Liu W, Zhao G, Yang W, Wang Y, Ma J, Shu Y, Lei F, Gao GF (2013) Origin and diversity of novel avian influenza A H7N9 viruses causing human inflection: phylogenetic, structural, and coalescent analyses. Lancet 381:1926–1932CrossRefPubMedGoogle Scholar
  10. Ma L, Jin T, Wang H, Liu H, Wang R, Li Y, Yang G, Xiong Y, Chen J, Zhang J, Chen G, Li W, Liu D, Lin P, Huang Y, Gao GF, Chen Q (2018) Two ressortant types of highly pathogenic H5N8 avian influenza virus from wild birds in Central China in 2016. Emerg Microbes Infect 7:14PubMedPubMedCentralGoogle Scholar
  11. Matrosovich M, Tuzikov A, Bovin N, Gambaryan A, Klimov A, Castrucci MR, Donatelli I, Kawaoka Y (2000) Early alterations of the receptor-binding properties of H1, H2 and H3 avian influenza virus hemagglutinins after their introduction into mammals. J Virol 74:8502–8512CrossRefPubMedPubMedCentralGoogle Scholar
  12. Monne I, Fusaro A, Nelson MI, Bonfanti L, Mulatti P, Hughes J, Murcia PR, Schivo A, Valastro V, Moreno A, Holmes EC, Cattoli G (2014) Emergence of a highly pathogenic avian influenza virus from a low-pathogenic progenitor. J Virol 88:4375–4388CrossRefPubMedPubMedCentralGoogle Scholar
  13. Munier S, Larcher T, Cormier-Aline F, Soubieux D, Su B, Guigand L, Labrosse B, Cherel Y, Quéré P, Marc D, Naffakh N (2010) A genetically engineered waterfowl influenza virus with a deletion in the stalk of the neuraminidase has increased virulence for chickens. J Virol 84:940–952CrossRefPubMedGoogle Scholar
  14. Qi W, Zhou X, Shi W, Huang L, Xia W, Liu D, Li H, Chen S, Lei F, Cao L, Wu J, He F, Song W, Li Q, Li H, Liao M, Liu M (2014) Genesis of the novel human-inflecting influenza A(H10N8) virus and potential genetic diversity of the virus in poultry, China. Euro Surveill 19:20841CrossRefPubMedGoogle Scholar
  15. Rambaut A, Lam TT, Max Carvalho L, Pybus OG (2016) Exploring the temporal structure of heterochronous sequences using TempEst (formerly Path-O-Gen). Virus Evol 2:vew007CrossRefPubMedPubMedCentralGoogle Scholar
  16. Senne DA, Panigrahy B, Kawaoka Y, Pearson JE, Süss J, Lipkind M, Kida H, Webster RG (1996) Survey of the hemagglutinin (HA) cleavage site sequence of H5 and H7 avian influenza viruses: amino acid sequence at the HA cleavage site as a marker of pathogenicity potential. Avian Dis 40:425–437CrossRefPubMedGoogle Scholar
  17. Spackman E, Swayne DE, Suarez DL, Senne DA, Pedersen JC, Killian ML, Pasick J, Handel K, Pillai SP, Lee CW, Stallknecht D, Slemons R, Ip HS, Deliberto T (2007) Characterization of low-pathogenicity H5N1 avian influenza viruses from North America. J Viorl 81:11612–11619CrossRefGoogle Scholar
  18. Wang D, Yang L, Gao R, Zhang X, Tan Y, Wu A, Zhu W, Zhou J, Zou S, Li X, et al (2013) Genetic turning of the novel avian influenza A(H7N9) virus during interspecies transmission, China, 2013. Euro Surveill 19:20836CrossRefGoogle Scholar
  19. Zhang F, Bi Y, Wang J, Wong G, Shi W, Hu F, Yang Y, Yang L, Deng X, Jiang S, He X, Liu Y, Yin C, Zhong N, Gao GF (2017) Human inflections with recently-emerging highly pathogenic H7N9 avian influenza virus in China. J Infect 75:71–75CrossRefPubMedGoogle Scholar

Copyright information

© Wuhan Institute of Virology, CAS 2019

Authors and Affiliations

  1. 1.CAS Key Laboratory of Special Pathogens and Biosafety, CAS Center for Influenza Research and Early Warning, Wuhan Institute of VirologyChinese Academy of SciencesWuhanChina
  2. 2.University of Chinese Academy of SciencesBeijingChina
  3. 3.China National Genebank-Shenzhen, BGI-ShenzhenShenzhenChina
  4. 4.Savaid Medical SchoolUniversity of Chinese Academy of SciencesBeijingChina
  5. 5.CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of MicrobiologyChinese Academy of SciencesBeijingChina

Personalised recommendations