Regulation of Virus Replication and T Cell Homeostasis by N6-Methyladenosine
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RNA modifications are abundant in eukaryotes, bacteria, and archaea. N6-methyladenosine (m6A), a type of RNA modification mainly found in messenger RNA (mRNA), has significant effects on the metabolism and function of mRNAs. This modification is governed by three types of proteins, namely methyltransferases as “writers”, demethylases as “erasers”, and specific m6A-binding proteins (YTHDF1-3) as “readers”. Further, it is important for the regulation of cell fate and has a critical function in many biological processes including virus replication, stem cell differentiation, and cancer development, and exerts its effect by controlling gene expression. Herein, we summarize recent advances in research on m6A in virus replication and T cell regulation, which is a rapidly emerging field that will facilitate the development of antiviral therapies and the study of innate immunity.
KeywordsRNA modification N6-methyladenosine (m6A) Virus replication T cell homeostasis
This study was supported by funding from the National Natural Science Foundation of China (Nos. 81672004, 31270202,81801993, and 81801994), the Jilin University Science and Technology Innovative Research Team (JLUSTIRT, 2017TD-05), the Science and Technology Department of Jilin Province (20160101044JC), the Health and Family Planning Commission of Jilin Province (2013Z066), the Key Laboratory of Molecular Virology, Jilin Province (20102209), and China Postdocotoral Science Foundation (2018M631869).
Compliance with Ethical Standards
Conflict of interest
The authors declare that they have no competing interests.
Animal and Human Rights Statement
This article does not contain any studies with human or animal subjects performed by any of the authors.
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