Prevalence of Kaposi’s sarcoma-associated herpesvirus in Uygur and Han populations from the Urumqi and Kashgar regions of Xinjiang, China
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Kaposi’s sarcoma-associated herpesvirus (KSHV) is the infectious etiologic agent associated with Kaposi’s sarcoma (KS), primary effusion lymphoma, and multicentric Castleman disease. It has been shown that high KSHV prevalence and high incidence of both classic KS and AIDSassociated KS are found mostly among people of Uygur ethnicity in Xinjiang, while people of Han ethnicity in Xinjiang have a higher KSHV seroprevalence than those of other Han populations in mainland China. However, it is still unclear why there is such geographical and population variation in KSHV distribution in China. In this work, we focused on the populations in the Kashgar region and Urumqi area, where a total of 1294 research subjects were randomly selected to investigate the potential correlation between KSHV prevalence and different ethnicities in endemic areas of Xinjiang, and to determine risk factors that may affect KSHV infection rates or KS incidence. We identified a high seroprevalence of KSHV and high peripheral blood DNA infection in the general Uygur and Han populations in both Urumqi and Kashgar regions of Xinjiang, and determined that advancing age, low education level, and stationary population status affect KSHV infection rates. Further, KSHV-positive Uygur participants were shown to have higher prevalence of neutralizing antibodies and neutralizing antibody titers than KSHV-positive Han participants.
KeywordsKaposi’s sarcoma associated herpesvirus (KSHV) prevalence Uygur ethnicity Han ethnicity Xinjiang
This study was supported by research grants from the National Natural Science Foundation of China (U1603117; 81560473; 81560442), Doctoral Foundation and Technology Research and Achievements Transformation Program of Xinjiang production and Construction Corps (2014BB021; 2015AD003), the United States National Institutes of Health Fogarty International Center (D43 TW001492), NCI (CA75903) and NCRR COBRE (RR15635) to C. Wood; Y. Zeng was a Fogarty Scholar.
YZ and TJZ designed the experiments. JZ, YY, MC and YZ carried out the experiments. ZJS, LLH and JZ acquired the clinical samples, ZQL and TJZ analyzed the data. CW provided scientific input. JZ and YZ wrote the manuscript. All authors read and approved the final manuscript.
Compliance with Ethics Guidelines
The authors declared that there is no conflict of interest. The study was approved by the Institutional Review Board of the University of Nebraska-Lincoln and the ethics board of Shihezi University, and written informed consent was obtained from all participants.
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