Lidocaine Microemulsion-Laden Organogels as Lipid-Based Systems for Topical Delivery

  • Rania HamedEmail author
  • Ahmad Farhan
  • Rana Abu-Huwaij
  • Nouf N. Mahmoud
  • Areej Kamal
Original Article



Conventional organogel and microemulsion-laden organogels (microemulsion organogels) were developed to deliver the lipophilic drug, lidocaine, topically.


Optimized formulations of lidocaine microemulsions of oil, water, and surfactant:cosurfactant (Tween® 20:ethanol), at ratios 4:1 and 2:1 v/v, were selected based on the droplet size and physical stability of microemulsions. Microemulsions were then loaded into organogels. Lidocaine conventional organogel was prepared without the addition of microemulsion and used as a reference. The rheological properties and release profiles of lidocaine organogels were investigated.


Lidocaine conventional and microemulsion organogels displayed viscoelastic properties with more elastic behavior. Lidocaine conventional organogel exhibited the highest viscoelastic properties and lowest rate of release, whereas microemulsion organogel containing Tween® 20:ethanol (4:1 v/v) exhibited lower viscoelastic properties and higher rate of release compared to those of microemulsion organogel containing Tween® 20:ethanol (2:1 v/v).


Type and composition of organogels dictated the viscoelastic properties and rate of release of lidocaine.


Microemulsion Organogels Rheology Controlled-release Topical delivery 


Funding Information

This project was financially supported by the Deanship of Academic Research and Graduate Studies at Al-Zaytoonah University of Jordan.

Compliance with Ethical Standards

Informed consent was obtained from the donor for study participation and the experimental protocols were approved by Al-Zaytoonah University of Jordan Research Ethics Committee (ZUJ-RES 2018/64/04) in adherence to Helsinki Guidelines.

Conflict of Interest

The authors declare that they have no conflict of interest.


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Pharmacy, Faculty of PharmacyAl-Zaytoonah University of JordanAmmanJordan
  2. 2.Department of Pharmaceutics & Pharmaceutical Technology, Faculty of PharmacyAl-Ahliyya Amman UniversityAmmanJordan

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