Fulminant mucormycosis after a traffic accident: a case report
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Mucormycosis is a rare fungal infection in immunocompetent patients, whereas in immunocompromised, it may be systemic and disseminated infection associated with high mortality. Mucormycosis is one of the most rapidly progressing and fulminant forms of fungal infections; Mucor circinelloides is rarely isolated species, also from immunocompromised patients. The reported case of mucormycosis after a traffic accident indicates that it may be the result of a contamination of wound by M. circinelloides coming from the environment. The fungal strain was identified by phenotypic methods and confirmed by molecular methods. Etest method was used for susceptibility testing of the fungal strain. No mycotoxins were detected in the analyzed sample. The infection was successfully treated with amphotericin B, but amputation of the lower limb was necessary.
This research was financially supported by the Nicolaus Copernicus University funds for the maintenance of the research potential of the Department of Microbiology.
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Conflict of interest
The authors declare that they have no conflict of interest.
- Arroyo MA, Schmitt BH, Davis TE, Relich RF (2016) Detection of the dimorphic phases of Mucor circinelloides in blood cultures from an immunosuppressed female. Case Rep Infect Dis. https://doi.org/10.1155/2016/3720549
- Dizbay M, Adisen E, Kustimur S (2009) Fungemia and cutaneous zygomycosis due to Mucor circinelloides in an intensive care unit patient: case report and review of literature. Jpn J Infect Dis 62:146–148Google Scholar
- Garcia-Hermoso D, Criscuolo A, Lee SC, Legrand M, Chaouat M, Denis B, Lafaurie M, Rouveau M, Soler C, Schaal JV, Mimoun M, Mebazaa A, Heitman J, Dromer F, Brisse S, Bretagne S, Alanio A (2018) Outbreak of invasive wound mucormycosis in a burn unit due to multiple strains of Mucor circinelloides f. circinelloides resolved by whole-genome sequencing. mBio 9:e00573–e00518CrossRefGoogle Scholar
- Hamdi T, Karthikeyan V, Alangaden GJ (2014) Mucormycosis in a renal transplant recipient: case report and comprehensive review of literature. Int J Nephrol. https://doi.org/10.1155/2014/950643
- Lee SC, Billmyre RB, Li A, Carson S, Sykes SM, Huh EY, Mieczkowski P (2014) Analysis of a food-borne fungal pathogen outbreak: virulence and genome of a Mucor circinelloides isolate from yogurt. mBio 5:e01390–e01314Google Scholar
- Pitt Ji and Hocking AD (1999) Fungi and Food Spoilage. Springer, pp 19–52Google Scholar
- Samson RA (2010) Food and indoor fungi. CBS-KNAW Fungal Biodiversity Centre Utrecht, The NetherlandsGoogle Scholar
- Stasiak M, Samet A, Lasek J, Wujtewicz M, Witkowski Z, Komarnicka J, Gołąbek-Dropiewska K, Rybak B, Gross M, Marks W (2009) Mucormycosis complicating lower limb crash injury in a multiple traumatised patient: an unusual case. BMJ Case. https://doi.org/10.1136/bcr.10.2008.1170
- Viegas C, Faria T, de Oliveira AC, Caetano LA, Carolino E, Quintal-Gomes A, Twarużek M, Kosicki R, Soszczyńska E, Viegas S (2017) A new approach to assess occupational exposure to airborne fungal contamination and mycotoxins of forklift drivers in waste sorting facilities. Mycotoxin Res 33:285–295CrossRefGoogle Scholar
- White TJ, Bruns T, Lee S, Taylor JW (1990) Amplification and direct sequencing of fungal ribosomal RNA genes for phylogenetics. In: Innis MA, Gelfand DH, Sninsky JJ, White TJ (eds) PCR protocols: a guide to methods and applications. Academic Press, Inc, New York www.uniprot.org/taxonomy (downloaded on 11/Feb/2018)Google Scholar