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Fibers and Polymers

, Volume 20, Issue 8, pp 1577–1585 | Cite as

Effect of Graphene Oxide Incorporation into Electrospun Cellulose Acetate Scaffolds on Breast Cancer Cell Culture

  • Yizao Wan
  • Zhonghong Lin
  • Deqiang Gan
  • Teng Cui
  • Meirong Wan
  • Fanglian Yao
  • Quanchao ZhangEmail author
  • Honglin LuoEmail author
Article
  • 46 Downloads

Abstract

Graphene-based nanomaterials have been used as biomaterials to enhance cell adhesion, growth, and differentiation. However, the effect of graphene materials on cancer cell behavior has not been thoroughly investigated. Herein, we have incorporated graphene oxide (GO) into cellulose acetate (CA) to develop nanofibrous scaffolds for in vitro cancer cell culture, which is a crucial step for drug screening and cancer research. The Go/CA scaffolds were seeded with breast cancer cells and cell viability, proliferation, adhesion, infiltration, and morphology were assessed. Mechanical characterization demonstrated that the mechanical properties of GO/CA scaffolds were significantly better than bare CA scaffold and improved with increasing GO content. More importantly, the in vitro cell studies showed that the cancer cells on GO/CA scaffolds had significantly higher viability and better cell adhesion and growth than bare CA. Our results confirm an important role of GO in improving mechanical properties and cancer cell performance on GO/CA scaffolds. These results suggest the potential of the GO/CA scaffolds as a promising candidate for in vitro cancer models.

Keywords

Graphene oxide Cellulose fibers Cancer model Scaffold 

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Notes

Acknowledgments

This work was supported by the Key Project of Natural Science Foundation of Jiangxi Province (Grant no. 20161ACB20018) and the National Natural Science Foundation of China (Grant nos. 31660264, 51572187).

Supplementary material

12221_2019_9133_MOESM1_ESM.pdf (3 mb)
Effect of Graphene Oxide Incorporation into Electrospun Cellulose Acetate Scaffolds on Breast Cancer Cell Culture

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Copyright information

© The Korean Fiber Society 2019

Authors and Affiliations

  • Yizao Wan
    • 1
    • 2
  • Zhonghong Lin
    • 1
  • Deqiang Gan
    • 1
  • Teng Cui
    • 1
  • Meirong Wan
    • 1
  • Fanglian Yao
    • 3
  • Quanchao Zhang
    • 1
    Email author
  • Honglin Luo
    • 1
    • 2
    Email author
  1. 1.Institute of Advanced MaterialsEast China Jiaotong UniversityNanchangChina
  2. 2.School of Materials Science and EngineeringTianjin UniversityTianjinChina
  3. 3.Key Laboratory of Systems Bioengineering of Ministry of Education, School of Chemical Engineering and TechnologyTianjin UniversityTianjinChina

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