Fibers and Polymers

, Volume 20, Issue 1, pp 19–24 | Cite as

Antimicrobial, Antibiofilm and Cytotoxicity Activity of a New Acridine Hyperbranched Polymer in Solution and on Cotton Fabric

  • Evgenia Vasileva-TonkovaEmail author
  • Desislava Staneva
  • Sandra Medel
  • Paula Bosch
  • Petar Grozdanov
  • Ivanka Nikolova
  • Ivo GrabchevEmail author


For the first time a fluorescent hyperbranched polymer modified with acridine (P1000-Acrid) was tested in vitro for antimicrobial activity against different model pathogens. The results showed strong activity of the compound against the used Gram-positive and Gram negative bacteria and yeasts. Cytotoxicity effect of P1000-Acrid has been studied towards HEp-2 cell line. The antibacterial finishing of cotton fabric treated with the P1000-Acrid was evaluated towards Grampositive and Gram-negative bacteria. It has been shown that the studied P1000-Acrid polymer reduces bacterial growth and prevents the formation of biofilm. The obtained results indicate that the studied P1000-Acrid hyperbranched polymer possess good antimicrobial potential with the greatest effectiveness against the used Gram-positive strains.


Hyperbranched polymer Acridine Antimicrobial activity Cytotoxicity Antibacterial cotton fabric 


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Copyright information

© The Korean Fiber Society 2019

Authors and Affiliations

  • Evgenia Vasileva-Tonkova
    • 1
    Email author
  • Desislava Staneva
    • 2
  • Sandra Medel
    • 3
  • Paula Bosch
    • 3
  • Petar Grozdanov
    • 1
  • Ivanka Nikolova
    • 1
  • Ivo Grabchev
    • 4
    Email author
  1. 1.The Stephan Angeloff Institute of MicrobiologyBulgarian Academy of SciencesSofiaBulgaria
  2. 2.University of Chemical Technology and MetallurgySofiaBulgaria
  3. 3.Institute of Science and Technology of PolymersICTR-CSICMadridSpain
  4. 4.Faculty of MedicineSofia University “St. Kliment Ohridski”SofiaBulgaria

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