Advertisement

Radiological Physics and Technology

, Volume 11, Issue 4, pp 415–422 | Cite as

Accurate and robust systolic myocardial T1 mapping using saturation recovery with individualized delay time: comparison with diastolic T1 mapping

  • Hideo Arai
  • Masateru Kawakubo
  • Kenichi Sanui
  • Hiroshi Nishimura
  • Toshiaki Kadokami
Article
  • 42 Downloads

Abstract

T1 mapping data are generally acquired in patients’ diastolic phase, wherein their myocardium is the thinnest in the cardiac cycle. However, the analysis of the thin myocardium may cause errors in image registrations and settings related to the region of interest. In this study, we validated systolic T1 mapping using the saturation recovery with individualized delay time (SR-IDT) method and compared it with conventional diastolic T1 mapping. Both diastolic and systolic T1 mappings were performed in the mid-ventricular plane in 10 healthy volunteers (35 ± 9 years, 9 males) and 29 consecutive patients with cardiac diseases (68 ± 14 years, 19 males). Comparison of the myocardial T1 value at diastole and systole was performed with both the Pearson correlation coefficient (r) and the Bland–Altman analysis. Additionally, the systolic myocardial T1 value was compared between the volunteers and patients by using Tukey’s test. Pearson correlation analysis demonstrated a strong positive correlation between diastolic and systolic T1 values (r = 0.88, P < 0.001). The Bland–Altman plot suggested that left ventricular T1 values in the diastole and systole showed high agreement (mean difference and 95% limits of agreement = 17 ± 104 ms). Further, systolic T1 values with SR-IDT in patients in the late gadolinium enhancement (LGE) group were significantly higher than those in the control group (1585 ± 118 ms vs 1469 ± 69 ms; P = 0.024). Therefore, the proposed systolic T1 mapping with the SR-IDT, which was validated with respect to the conventional diastolic method, is a useful clinical tool for the quantitative characterization of the myocardium.

Keywords

T1 mapping Myocardium Systole Saturation recovery Cardiovascular magnetic resonance imaging 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Statement of human and animal rights

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Institutional Review Board (IRB) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies performed with animals.

Informed consent

Informed consent was obtained from all individual participants included in the study.

References

  1. 1.
    Bulluck H, Hammond-Haley M, Fontana M, Knight DS, Sirker A, Herrey AS, Manisty C, Kellman P, Moon JC, Hausenloy DJ. Quantification of both the area-at-risk and acute myocardial infarct size in ST-segment elevation myocardial infarction using T1-mapping. J Cardiovasc Magn Reson. 2017;19:57.CrossRefGoogle Scholar
  2. 2.
    Taylor AJ, Salerno M, Dharmakumar R, Jerosch-Herold M. T1 mapping: basic techniques and clinical applications. JACC Cardiovasc Imaging. 2016;9:67–81.CrossRefGoogle Scholar
  3. 3.
    Bulluck H, Maestrini V, Rosmini S, Abdel-Gadir A, Treibel TA, Castelletti S, Bucciarelli-Ducci C, Manisty C, Moon JC. Myocardial T1 mapping. Circ J. 2015;79:487–94.CrossRefGoogle Scholar
  4. 4.
    Ferreira VM, Piechnik SK, Dall’Armellina E, Karamitsos TD, Francis JM, Ntusi N, Holloway C, Choudhury RP, Kardos A, Robson MD, Friedrich MG, Neubauer S. Native T1-mapping detects the location, extent and patterns of acute myocarditis without the need for gadolinium contrast agents. J Cardiovasc Magn Reson. 2014;16:36.CrossRefGoogle Scholar
  5. 5.
    Dass S, Suttie JJ, Piechnik SK, Ferreira VM, Holloway CJ, Banerjee R, Mahmod M, Cochlin L, Karamitsos TD, Robson MD, Watkins H, Neubauer S. Myocardial tissue characterization using magnetic resonance noncontrast t1 mapping in hypertrophic and dilated cardiomyopathy. Circ Cardiovasc Imaging. 2012;5:726–33.CrossRefGoogle Scholar
  6. 6.
    Hamdy A, Kitagawa K, Ishida M, Sakuma H. Native myocardial T1 mapping, are we there yet? Int Heart J. 2016;57:400–7.CrossRefGoogle Scholar
  7. 7.
    Pagano JJ, Chow K, Khan A, Michelakis E, Paterson I, Oudit GY, Thompson RB. Reduced right ventricular native myocardial T1 in Anderson-fabry disease: comparison to pulmonary hypertension and healthy controls. PLoS One. 2016;11:e0157565.CrossRefGoogle Scholar
  8. 8.
    Germain P, El Ghannudi S, Jeung MY, Ohlmann P, Epailly E, Roy C, Gangi A. Native T1 mapping of the heart—a pictorial review. Clin Med Insights Cardiol. 2014;8:1–11.PubMedPubMedCentralGoogle Scholar
  9. 9.
    Puntmann VO, Peker E, Chandrashekhar Y, Nagel E. T1 mapping in characterizing myocardial disease: a comprehensive review. Circ Res. 2016;119:277–99.CrossRefGoogle Scholar
  10. 10.
    Roujol S, Weingartner S, Foppa M, Chow K, Kawaji K, Ngo LH, Kellman P, Manning WJ, Thompson RB, Nezafat R. Accuracy, precision, and reproducibility of four T1 mapping sequences: a head-to-head comparison of MOLLI, ShMOLLI, SASHA, and SAPPHIRE. Radiology. 2014;272:683–9.CrossRefGoogle Scholar
  11. 11.
    Chow K, Flewitt JA, Green JD, Pagano JJ, Friedrich MG, Thompson RB. Saturation recovery single-shot acquisition (SASHA) for myocardial T(1) mapping. Magn Reson Med. 2014;71:2082–95.CrossRefGoogle Scholar
  12. 12.
    Piechnik SK, Ferreira VM, Dall’Armellina E, Cochlin LE, Greiser A, Neubauer S, Robson MD. Shortened modified look-locker inversion recovery (ShMOLLI) for clinical myocardial T1-mapping at 1.5 and 3 T within a 9 heartbeat breathhold. J Cardiovasc Magn Reson. 2010;12:69.CrossRefGoogle Scholar
  13. 13.
    Fitts M, Breton E, Kholmovski EG, Dosdall DJ, Vijayakumar S, Hong KP, Ranjan R, Marrouche NF, Axel L, Kim D. Arrhythmia insensitive rapid cardiac T1 mapping pulse sequence. Magn Reson Med. 2013;70:1274–82.CrossRefGoogle Scholar
  14. 14.
    Kawel-Boehm N, Dellas Buser T, Greiser A, Bieri O, Bremerich J, Santini F. In-vivo assessment of normal T1 values of the right-ventricular myocardium by cardiac MRI. Int J Cardiovasc Imaging. 2014;30:323–8.CrossRefGoogle Scholar
  15. 15.
    Reiter U, Reiter G, Dorr K, Greiser A, Maderthaner R, Fuchsjager M. Normal diastolic and systolic myocardial T1 values at 1.5-T MR imaging: correlations and blood normalization. Radiology. 2014;271:365–72.CrossRefGoogle Scholar
  16. 16.
    Ferreira VM, Wijesurendra RS, Liu A, Greiser A, Casadei B, Robson MD, Neubauer S, Piechnik SK. Systolic ShMOLLI myocardial T1-mapping for improved robustness to partial-volume effects and applications in tachyarrhythmias. J Cardiovasc Magn Reson. 2015;17:77.CrossRefGoogle Scholar
  17. 17.
    Tessa C, Diciotti S, Landini N, Lilli A, Del Meglio J, Salvatori L, Giannelli M, Greiser A, Vignali C, Casolo G. Myocardial T1 and T2 mapping in diastolic and systolic phase. Int J Cardiovasc Imaging. 2015;31:1001–10.CrossRefGoogle Scholar
  18. 18.
    Zhao L, Li S, Ma X, et al Zhao L, Li S, Ma X, Greiser A, Zhang T, An J, Bai R, Dong J, Fan Z. Systolic MOLLI T1 mapping with heart-rate-dependent pulse sequence sampling scheme is feasible in patients with atrial fibrillation. J Cardiovasc Magn Reson. 2016;18:13.CrossRefGoogle Scholar
  19. 19.
    Messroghli DR, Radjenovic A, Kozerke S, Higgins DM, Sivananthan MU, Ridgway JP. Modified look-locker inversion recovery (MOLLI) for high-resolution T1 mapping of the heart. Magn Reson Med. 2004;52:141–6.CrossRefGoogle Scholar
  20. 20.
    Kanda Y. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transpl. 2013;48:452–8.CrossRefGoogle Scholar
  21. 21.
    Diao KY, Yang ZG, Xu HY, Liu X, Zhang Q, Shi K, Jiang L, Xie LJ, Wen LY, Guo YK. Histologic validation of myocardial fibrosis measured by T1 mapping: a systematic review and meta-analysis. J Cardiovasc Magn Reson. 2016;18:92.CrossRefGoogle Scholar
  22. 22.
    Rashid MA, Qureshi BA, Ahmed N, Sherwani MA. Impact of body mass index on left ventricular mass. J Ayub Med Coll Abbottabad. 2014;26:167–9.PubMedGoogle Scholar
  23. 23.
    Moon JC, Messroghli DR, Kellman P, Piechnik SK, Robson MD, Ugander M, Gatehouse PD, Arai AE, Friedrich MG, Neubauer S, Schulz-Menger J, Schelbert EB. Myocardial T1 mapping and extracellular volume quantification: a Society for Cardiovascular Magnetic Resonance (SCMR) and CMR Working Group of the European Society of Cardiology consensus statement. J Cardiovasc Magn Reson. 2013;15:92.CrossRefGoogle Scholar

Copyright information

© Japanese Society of Radiological Technology and Japan Society of Medical Physics 2018

Authors and Affiliations

  • Hideo Arai
    • 1
  • Masateru Kawakubo
    • 2
  • Kenichi Sanui
    • 1
  • Hiroshi Nishimura
    • 1
  • Toshiaki Kadokami
    • 1
  1. 1.Fukuokaken Saiseikai Futsukaichi HospitalFukuokaJapan
  2. 2.Department of Health Sciences, Faculty of Medical SciencesKyushu UniversityFukuokaJapan

Personalised recommendations