Cell Stress and Chaperones

, Volume 24, Issue 1, pp 1–6 | Cite as

The IXth CSSI international symposium on heat shock proteins in biology and medicine: stress responses in health and disease

Alexandria Old Town, Alexandria, Virginia, November 10–13, 2018
  • Stuart K. Calderwood
  • Elizabeth A. Repasky
  • Len Neckers
  • Lawrence E. HightowerEmail author
Meeting Review


The stress response has been studied now for over 50 years and is known to have significance in the survival of organisms in a challenging environment and in the healthy development of all known descendants of the last common universal ancestor (LUCA). This meeting was concentrated mostly on the responses of cells and organisms to environmental and cell stress including the impact of thermal stress, which was a major theme throughout this meeting. One emphasis was on the deployment of the heat shock response that permits damage to proteins to be detected and responded to by the abundant synthesis of heat shock proteins (HSPs). Speakers and presenters of posters responded to the questions of how are the HSPs rapidly induced by stressors? By which mechanisms are they are regulated in the cell by protein-protein interactions or posttranslational modification? And, what are the consequences when these abundantly expressed proteins escape the confines of the cell and influence the extracellular microenvironment? Key among the questions was how does stress influence longevity and aging and what happens in terms of disease control (malignant, neurodegenerative) when stress responses become compromised? In this context, many presenters addressed the question of pharmacologically modifying the heat shock response and HSP functions and thus improving responses to a range of disease types.


CSSI symposium Heat shock proteins Stress responses Cancer biology Proteostasis Caloristasis Hsp90 Hsp70 



We wish to thank our sponsoring organizations including the Cell Stress Society International, Springer Nature, MGM Resorts International, and StressMarq Biosciences for their continued support without which this symposium would not have been possible. A special thanks to CSSI General Secretary Helen Neumann who handled all of the details of meeting organization.

Supplementary material

12192_2018_966_MOESM1_ESM.pdf (759 kb)
ESM 1 (PDF 758 kb)

Copyright information

© Cell Stress Society International 2019

Authors and Affiliations

  • Stuart K. Calderwood
    • 1
  • Elizabeth A. Repasky
    • 2
  • Len Neckers
    • 3
  • Lawrence E. Hightower
    • 4
    Email author
  1. 1.Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonUSA
  2. 2.Roswell Park Cancer CenterBuffaloUSA
  3. 3.National Cancer Institute, National Institutes of HealthBethesdaUSA
  4. 4.University of ConnecticutStorrsUSA

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