International Journal of Hematology

, Volume 110, Issue 1, pp 50–58 | Cite as

Current and future perspectives on allogeneic transplantation using ex vivo expansion or manipulation of umbilical cord blood cells

  • Ko K. MaungEmail author
  • Mitchell E. Horwitz
Progress in Hematology Recent progress in allogeneic stem cell transplantation using alternative stem cell sources


In patients with hematologic malignancies, the outcome of umbilical cord blood transplantation has improved and is now comparable to that of matched unrelated donor transplantation. However, the limitation of using umbilical cord blood has been a delay in both hematopoietic and immunologic recovery. Strategies have been proposed to overcome these limitations. One strategy involves ex vivo expansion of the umbilical cord blood unit prior to transplantation. A second strategy involves exposure of the umbilical cord blood graft to compounds aimed at improving homing and engraftment following transplantation. Many of these strategies are now being tested in late phase multi-center clinical trials. If proven cost effective and efficacious, they may alter the landscape of donor options for allogeneic stem cell transplantation.


Umbilical cord blood Expansion Manipulation Stem cell transplantation Hematopoietic recovery Hematopoietic progenitor cell 


Compliance with ethical standards

Conflict of interest

Ko Maung does not report any conflict of interest. He is supported by NIH T32HL007057 grant. Mitchell Horwitz has received research support from, and has served as a consultant for Gamida Cell Ltd.


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Copyright information

© Japanese Society of Hematology 2019

Authors and Affiliations

  1. 1.Hematology and Medical Oncology FellowDuke University School of MedicineDurhamUSA
  2. 2.Adult Blood and Marrow Transplant ProgramDuke University School of MedicineDurhamUSA

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