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International Journal of Hematology

, Volume 108, Issue 5, pp 554–557 | Cite as

Successful treatment of cytarabine-related neurotoxicity with corticosteroids, a case series

  • Jennifer L. Dotson
  • Muhammad Omer Jamil
Case Report
  • 116 Downloads

Abstract

Neurotoxicity from high-dose cytarabine, a pyrimidine metabolite used in treatment for acute myeloid leukemia, is a known but dose-limiting toxicity which has incidences in up to 14% in patients receiving high doses of the drug. Neurologic symptoms vary but range from somnolence and ataxia to more severe complications such as seizures and even death. There are no validated treatments other than discontinuation of the drug and supportive measures. We present two cases of cytarabine-related neurotoxicity treated with corticosteroids with complete resolution of symptoms.

Keywords

Cytarabine Acute myeloid leukemia Neurotoxicity 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

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Copyright information

© The Japanese Society of Hematology 2018

Authors and Affiliations

  1. 1.Department of Hematology and OncologyMarshall UniversityHuntingtonUSA

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