International Journal of Hematology

, Volume 108, Issue 3, pp 237–238 | Cite as

Severe acyclovir-resistant herpes simplex virus 1 infection following cord blood transplantation

  • Tomonari Shigemura
  • Yozo NakazawaEmail author
  • Tomoki Yoshikawa
  • Hikaru Fujii
  • Souichi Yamada
  • Masayuki Saijo
  • Ryuhei Okuyama
Images in Hematology


Acyclovir-resistant herpes simplex virus 1 Skin lesion Cord blood transplantation Foscarnet 



This work was supported by JSPS KAKENHI Grant number 17K10104. The authors would like to thank Enago ( for the English language review and Ms. Yūka Miyajima for assistance with preparing the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


  1. 1.
    Kawamura K, Hayakawa J, Akahoshi Y, Harada N, Nakano H, Kameda K, et al. Low-dose acyclovir prophylaxis for the prevention of herpes simplex virus and varicella zoster virus diseases after autologous hematopoietic stem cell transplantation. Int J Hematol. 2015;102(2):230–7.CrossRefPubMedGoogle Scholar
  2. 2.
    Schmidt S, Bohn-Wippert K, Schlattmann P, Zell R, Sauerbrei A. Sequence analysis of herpes simplex virus 1 thymidine kinase and DNA polymerase genes from over 300 clinical isolates from 1973 to 2014 finds novel mutations that may be relevant for development of antiviral resistance. Antimicrob Agents Chemother. 2015;59(8):4938–45.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© The Japanese Society of Hematology 2018

Authors and Affiliations

  1. 1.Department of PediatricsShinshu University School of MedicineMatsumotoJapan
  2. 2.Herpes Virus Laboratory, Department of Virology INational Institute of Infectious DiseasesTokyoJapan
  3. 3.Department of DermatologyShinshu University School of MedicineMatsumotoJapan

Personalised recommendations