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International Journal of Hematology

, Volume 108, Issue 3, pp 282–289 | Cite as

Refinement of the Glasgow Prognostic Score as a pre-transplant risk assessment for allogeneic hematopoietic cell transplantation

  • Yasuhiko Shibasaki
  • Tatsuya Suwabe
  • Takayuki Katagiri
  • Tomoyuki Tanaka
  • Takashi Ushiki
  • Kyoko Fuse
  • Naoko Sato
  • Toshio Yano
  • Takashi Kuroha
  • Shigeo Hashimoto
  • Miwako Narita
  • Tatsuo Furukawa
  • Hirohito Sone
  • Masayoshi Masuko
Original Article
  • 145 Downloads

Abstract

The Hematopoietic Cell Transplantation-specific Comorbidity Index (HCT-CI) is a widely used tool for pre-transplant risk assessment. Allogeneic hematopoietic cell transplantation (HCT) is performed on patients with diverse backgrounds, highlighting the need for other predictors to complement the HCT-CI and support bedside decision-making. There is a strong body of evidence supporting the use of pre-transplant serum ferritin (SF) in risk assessments of allogeneic HCT. We additionally found that the Glasgow Prognostic Score (GPS), which assesses inflammatory biomarkers and predicts survival of patients with solid organ malignancies, is a useful predictive marker for overall survival (OS) and non-relapse mortality (NRM) in allogeneic HCT, independent of HCT-CI and SF. In this study, we refined the GPS by adding pre-transplant SF to improve its prognostic ability and enable better stratification; we call this revised index the HCT-specific revised Glasgow Prognostic Score (HCT-GPS). We observed that the HCT-GPS more accurately predicted NRM and early-term OS than the GPS. Moreover, the HCT-GPS provides an independent prognostic factor adjusted for the HCT-CI and disease status, and stratifies patients into four risk groups by OS and NRM. Thus, the HCT-GPS is a useful index for predicting early-term complications after allogeneic HCT in patients with hematopoietic diseases.

Keywords

Hematopoietic cell transplantation Risk assessment Biomarkers Predictive score 

Notes

Acknowledgements

The authors would like to thank the medical staff at each transplantation center.

Author contributions

YS performed research, TS, TK, TT, KF, TU, NS, TY, TK, SH, MN, TF, and HS performed data analysis, YS and MM wrote the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.

Supplementary material

12185_2018_2463_MOESM1_ESM.docx (23 kb)
Supplementary material 1 (DOCX 22 KB)
12185_2018_2463_MOESM2_ESM.tif (158 kb)
Supplemental figure 1: Kaplan–Meier estimates of overall survival (a) and non-relapse mortality (b) using the Glasgow Prognostic Score (GPS). 1 year-mortality in each risk-group of the GPS was as follows, OS 0: 70.3%, 1: 50.0%, 2: 15.8% (a), NRM 0: 19.6%, 1: 28.6%, 2: 52.6% (b). (TIF 158 KB)

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Copyright information

© The Japanese Society of Hematology 2018

Authors and Affiliations

  • Yasuhiko Shibasaki
    • 1
    • 2
  • Tatsuya Suwabe
    • 2
  • Takayuki Katagiri
    • 2
  • Tomoyuki Tanaka
    • 2
  • Takashi Ushiki
    • 2
  • Kyoko Fuse
    • 2
  • Naoko Sato
    • 3
  • Toshio Yano
    • 3
  • Takashi Kuroha
    • 3
  • Shigeo Hashimoto
    • 3
  • Miwako Narita
    • 2
  • Tatsuo Furukawa
    • 3
  • Hirohito Sone
    • 2
  • Masayoshi Masuko
    • 1
  1. 1.Department of Stem Cell TransplantationNiigata University Medical and Dental HospitalNiigataJapan
  2. 2.Department of Hematology, Endocrinology and MetabolismNiigata University Faculty of MedicineNiigataJapan
  3. 3.Department of HematologyNagaoka Red Cross HospitalNagaokaJapan

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