A Review of the Use of Cryoballoon Ablation for the Treatment of Persistent Atrial Fibrillation
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Purpose of Review
Cryoballoon ablation is the standard-of-care treatment for patients with paroxysmal atrial fibrillation, but its efficacy in addressing persistent atrial fibrillation is unclear. Current research is underway to identify origins of persistent atrial fibrillation in locations outside of the pulmonary veins, which are likely high-yield targets for catheter ablation.
Randomized studies suggest that targeting non-pulmonary vein (PV) locations has not proven to significantly improve outcomes in patients with persistent atrial fibrillation. A growing body of evidence suggests that cryoballoon ablation achieves freedom from persistent atrial fibrillation with pulmonary vein isolation alone.
Use of cryoballoon ablation for non-PV regions is ongoing but still novel. Application of the cryoballoon to non-PV regions may improve with further development of the cryoballoon catheter.
KeywordsPersistent atrial fibrillation PerAF Catheter ablation Cryoballoon
Compliance with Ethical Standards
Conflict of Interest
All the authors declare that they have no conflict of interest.
Human and Animal Rights and Informed Consent
All reported studies/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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