A Review of the Use of Cryoballoon Ablation for the Treatment of Persistent Atrial Fibrillation

  • Emrie Tomaiko
  • Neal Bhatia
  • Wilber SuEmail author
Arrhythmias (J. Bunch, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Arrythmias


Purpose of Review

Cryoballoon ablation is the standard-of-care treatment for patients with paroxysmal atrial fibrillation, but its efficacy in addressing persistent atrial fibrillation is unclear. Current research is underway to identify origins of persistent atrial fibrillation in locations outside of the pulmonary veins, which are likely high-yield targets for catheter ablation.

Recent Findings

Randomized studies suggest that targeting non-pulmonary vein (PV) locations has not proven to significantly improve outcomes in patients with persistent atrial fibrillation. A growing body of evidence suggests that cryoballoon ablation achieves freedom from persistent atrial fibrillation with pulmonary vein isolation alone.


Use of cryoballoon ablation for non-PV regions is ongoing but still novel. Application of the cryoballoon to non-PV regions may improve with further development of the cryoballoon catheter.


Persistent atrial fibrillation PerAF Catheter ablation Cryoballoon 


Compliance with Ethical Standards

Conflict of Interest

All the authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

All reported studies/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Stanford University School of MedicinePhoenixUSA
  2. 2.Banner Heart InstitutePhoenixUSA

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