Well-Designed High Selective Carbon Molecularly Imprinted Polymer Nanocomposite Based on a Green Synthesis Strategy for Solid-Phase Extraction of Tetracyclines Residues in Food Samples Article First Online: 03 August 2019 Abstract
Herein, a well-designed hydrophilic tetracycline-imprinted polymer with high selectivity was synthesized with a three-dimensional carbon nanocomposite of graphene oxide (GO) and carbon nanotube (CNT) by a green synthesis method of freeze-drying. The synthesized materials with super selectivity, which could distinguish high similar structural analogues of tetracycline (TC) and oxytetracycline (OTC), and the maximum adsorption capacity for TC (MW 444.44, 19.31 mg g
−1) was 3-fold greater than its structural analogue of OTC (MW 460.43, 6.48 mg g −1). The synthesized materials were characterized by Fourier-transform infrared spectrometry (FT-IR), scanning electron microscopy (SEM), Brunauer–Emmett–Teller (BET), and thermogravimetry analysis (TGA). The adsorption mechanism and adsorption performance of the synthesized materials were detailed studied via the adsorption isotherms, adsorption kinetics, competitive adsorption, and selective adsorption experiments. A method was established by using the synthesized materials as the adsorbent for solid-phase extraction (SPE) of TCs residues in food samples and then detected by high-performance liquid chromatography (HPLC). Under the optimum conditions, the detection limit of this method (MDL) was 0.127 μg kg −1. The extraction efficiency of this method was performed in three real samples (milk, chicken, and fish) that spiked with tetracycline of three levels (5, 10, 20 μg kg −1). The results showed good recoveries ranging from 85.58 ± 0.19 to 116.87 ± 8.92% ( S/ N = 3), respectively. Keywords Tetracyclines Molecularly imprinting polymers Carbon composite Solid-phase extraction High-performance liquid chromatography Highlights
• Well-designed high selective carbon molecularly imprinted polymer nanocomposite synthesized by a green synthesis method of freeze-drying.
• Carbon nanocomposite of GGO@CNTs could enhance the selectivity of MIPs for tetracycline.
• The synthesized GGO@CNTs-MIP could distinguish high similar structural analogues of tetracycline (TC) and oxytetracycline (OTC).
Notes Funding Information
This work was supported by the National Natural Science Foundation of China (No. 31301470).
Compliance with Ethical Standards Conflict of Interest
Jinxing He declares that he has no conflict of interest. Yuxia Huang declares that she has no conflict of interest. Tao Zhao declares that she has no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
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