Urazole-Au Nanocluster as a Novel Fluorescence Probe for Curcumin Determination and Mitochondria Imaging

  • Rui Yang
  • Wei-Yu Mu
  • Qiu-Yun ChenEmail author


Curcumin (CUR), a natural plant product, is widely used in food and medicine. The determination of CUR in medicine and food will be important to control the quality of CUR containing products. Herein, a new kind of fluorescence urazole-Au clusters (Urazole-AuNCs) has been synthesized successfully via one-step method using urazole and polyvinyl pyrrolidone (PVP) as templates. The fluorescence emission intensity of Urazole-AuNCs at 473 nm is sensitive to the concentration of CUR. Therefore, a fluorescence method for the quantitative detection of CUR was built using Urazole-AuNCs as the fluorescence sensor with detection limit of 72 nM. This method was successfully used to quantitatively monitor CUR in curry powder; Urazole-AuNC-based fluorescence method can be a good technique for quantitative detection of CUR and differentiation of CUR from others. Furthermore, the novel low-toxic urazole-Au clusters could be used for mitochondrial targeted imaging of cancer cells.


Urazole AuNCs Curcumin Detection Fluorescence Technique 


Funding Information

This work was financially supported by the National Natural Science Foundation of China (21571085).

Compliance with Ethical Standards

Conflict of Interest

Rui Yang declares that he has no conflict of interest. Weiyu Mu declares that she has no conflict of interest. Qiuyun Chen declares that she has no conflict of interest.

Ethical Approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed Consent

Not applicable.

Supplementary material

12161_2019_1519_MOESM1_ESM.doc (656 kb)
ESM 1 (DOC 656 kb)


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Institute of Chemistry and Chemical EngineeringJiangsu UniversityZhenjiangPeople’s Republic of China

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