Determination of Malachite Green in Fish by a Modified MOF-Based Electrochemical Sensor

  • Yanli ZhouEmail author
  • Xiaoqiao Li
  • Zhonghao Pan
  • Baoxian Ye
  • Maotian Xu


Cu-based metal-organic frameworks modified by silver (Ag/Cu-MOFs) were in situ fabricated through a one-step direct synthesis. The as-prepared mixed-node MOFs were modified on glassy carbon (GC) electrode, which was utilized as a voltammetric sensor for probing malachite green. Compared with the bare GC electrode, the introduced Ag/Cu-MOF film on the electrode surface dramatically improved the sensitivity of the sensor response according to the accumulation and catalytic activity of Ag/Cu-MOFs for malachite green. The developed electrochemical sensor exhibited a low detection limit of 2.2 nM with a wide linear range of 10–140 nM and high anti-interference ability. The feasibility of the assay was verified by test of malachite green in fish sample. The proposed strategy presents valuable information for the evaluation of the food safety in aquaculture industry.


Cu-based metal-organic frameworks (Cu-MOFs) Silver modification Electrochemical sensor Malachite green Fish sample 



This work was supported by grants from the National Natural Science Foundation of China (Grant Nos. 21675109), the Central Thousand Talents Plan (No. ZYQR201810151), the Natural Science Foundation of Henan Province (162300410209), and Henan Joint International Research Laboratory of Chemo/Biosensing and Early Diagnosis of Major Diseases.

Compliance with Ethical Standards

Conflict of Interest

Yanli Zhou declares that she has no conflict of interest. Xiaoqiao Li declares that she has no conflict of interest. Zhonghao Pan declares that he has no conflict of interest. Baoxian Ye declares that he has no conflict of interest. Maotian Xu declares that he has no conflict of interest.

Ethical Approval

This article does not contain any studies with human participants performed by any of the authors.

Informed Consent

Not applicable.


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Authors and Affiliations

  1. 1.Henan Key Laboratory of Biomolecular Recognition and Sensing, College of Chemistry and Chemical EngineeringShangqiu Normal UniversityShangqiuPeople’s Republic of China
  2. 2.College of Chemistry and Molecular EngineeringZhengzhou UniversityZhengzhouPeople’s Republic of China

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