Automatically High-Throughput Quantification by Paper Spray Ionization Mass Spectrometry for Multiple Pesticides in Wine
A rapid paper spray (PS) ionization tandem mass spectrometry analytical method has been developed to determine multiple pesticides in red wine. Without chromatographic separation, 36 pesticides in wine could be simultaneously determined less than 9 and 3 min, followed by off-line QuEChERS treatment and on-line paper adsorption treatment, respectively. Isotopically labeled internal standard (IS) was utilized to calibrate injection process, and linear ranges were one to three orders of magnitude for different pesticides. LODs were ranging between 0.1 and 100 ng/mL, and LOQs were ranging between 0.3 and 300 ng/mL. Method validation was used to evaluate the accuracy and precision, and the results for most analytes were at the range of 75–120%. All the data processes were automatically achieved by build-in instrument software. These methods were also compared with QuEChERS-DART-MS/MS and DART-MS/MS. The results demonstrated that PS-MS/MS was a rapid and simple method to quantify multiple pesticides in red wine.
KeywordsAutomatically high-throughput quantification Paper spray (PS) ionization Tandem mass spectrometry Pesticide Red wine QuEChERS Paper adsorption Ambient Rapid
Authors wish to thank the support of Tianyang Guo through the CSC Scholarship Program from BUCT.
Authors are also grateful to R. Graham Cooks, Karen E. Yannell, Qiang Ma, Fan Pu, and Pingping Fang for helpful advice.
This study was funded by the National Key R&D Program of China (2016YFF0203703), the Key Program of a Synchronized Detection Research and Risk Assessment for Radionuclides in Foods of Beijing Municipal Science & Technology Commission (D161100002116002), and NSFC grant (51673012).
Compliance with Ethical Standards
Conflict of Interest
Tianyang Guo declares that she has no conflict of interest. Wei Yong declares that he has no conflict of interest. Yiyang Dong declares that he has no conflict of interest.
This article does not contain any studies with human participants or animals.
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