Brain 18F-FDG distribution: which region is most affected by increased plasma glucose levels?
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Both similarities and differences can be found between the Alzheimer’s Disease Neuroimaging Initiative studies in North America (ADNI) and Japan (J-ADNI) as recently shown by Iwatsubo and colleagues . Here, we present an example of the difference in 18F-FDG data between the two multicenter studies.
Our series of studies has shown that increased plasma glucose levels can alter the brain 18F-FDG distribution pattern from normal to Alzheimer’s disease (AD) like . Apostolova and colleagues recently confirmed this phenomenon using 18F-FDG images of normal subjects (n = 87, 74.2 ± 5.3 years) from the ADNI study . Additionally, they observed that the occipital cortex was one of the preferential areas where increased plasma glucose levels decreased 18F-FDG uptake. However, this occipital cortex change was not detected in our series of studies  or other relevant studies . Therefore, we are concerned about the detection of the occipital cortex in the study by Apostolova...
Keywords18F-FDG Positron emission tomography Glucose
The data used for this research were originally obtained by the Japanese Alzheimer’s Disease Neuroimaging Initiative (J-ADNI) led by Prof. Takeshi Iwatsubo and available at the website of the National Bioscience Database Center/the Japan Science and Technology Agency. J-ADNI Study Group provided data but did not participate in the analysis or writing of this research. A complete listing of J-ADNI investigators can be found at: https://humandbs.biosciencedbc.jp/en/hum0043-j-adni-authors.
All authors designed the study. Ishibashi carried out the data processing. All authors interpreted the data. Ishibashi drafted the manuscript. All authors read and approved the final manuscript.
The authors received no funding for this study.
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Conflict of interest
The authors declare that they have no competing interests.