Sprayed liquid-gas extraction in combination with ion mobility spectrometry: a novel approach for the fast determination of semi-volatile compounds in air and from contaminated surfaces

  • Mashaalah Zarejousheghani
  • Malcolm Cämmerer
  • Thomas Mayer
  • Andreas Walte
  • Helko Borsdorf
Original Research
  • 27 Downloads

Abstract

We developed a fast, simple and highly-efficient enrichment procedure for trace levels of semi volatile organic compounds from air and surfaces and combined it with ion mobility spectrometry as field-deployable and rapid analytical technique. Our new technique, the sprayed liquid-gas extraction, was developed and optimized to allow the enrichment of semi volatile organic compounds. The air sample is pumped through a flow blurring nebulizer together with water. The sprayed liquid is collected and the organic compounds are transferred from the water phase to n-hexane via a miniscale liquid-liquid extraction. 50 μL of the n-hexane extract is applied to a fiber tape. After the n-hexane has evaporated, the fiber tape is transferred to the thermodesorber unit of a GDA-X ion mobility spectrometer (Airsense, Schwerin, Germany). The whole sampling and the sample preparation procedure takes no longer than 15 min and only requires 2.5 mL organic solvent. The method was optimized for Malathion, a widely used organophosphate insecticide and an accepted simulant for the nerve-agent, VX. Malathion provides defined ion mobility spectra in both, the positive and negative mode. The positive spectra show one major peak with a reduced mobility of 1.197 cm2 Vs−1 and an additional peak at 1.449 cm2 Vs−1 with lower intensity. A major product ion peak of 1.720 cm2 Vs−1 can be detected in negative mode together with an additional peak of low intensity at 1.403 cm2 Vs−1. The detection limit of the ion mobility spectrometer is approximately 20 ng absolute.

Keywords

Sprayed liquid gas extraction Thermodesorption Ion mobility spectrometry 

Notes

Acknowledgements

The authors gratefully acknowledge the financial support by the TOXI-Triage project (Tools for detection, traceability, triage and individual monitoring of victims) which is funded from the European Union’s Horizon 2020 (H2020) research and innovation program under the Grant Agreement no 653409.

References

  1. 1.
    Võ U-UT, Morris MP (2014) Nonvolatile, semivolatile, or volatile: Redefining volatile for volatile organic compounds. J Air Waste Manage Assoc 64(6):661–669.  https://doi.org/10.1080/10962247.2013.873746 CrossRefGoogle Scholar
  2. 2.
    Woolfenden E (2010) Sorbent-based sampling methods for volatile and semi-volatile organic compounds in air: part 1: sorbent-based air monitoring options. J Chrom A 1217(16):2674–2684.  https://doi.org/10.1016/j.chroma.2009.12.042 CrossRefGoogle Scholar
  3. 3.
    Woolfenden E (2010) Sorbent-based sampling methods for volatile and semi-volatile organic compounds in air. Part 2. Sorbent selection and other aspects of optimizing air monitoring methods. J Chrom A 1217(16):2685–2694.  https://doi.org/10.1016/j.chroma.2010.01.015 CrossRefGoogle Scholar
  4. 4.
    Kalina J, Scheringer M, Borůvková J, Kukučka P, Přibylová P, Bohlin-Nizzetto P, Klánová J (2017) Passive air samplers as a tool for assessing long-term trends in atmospheric concentrations of Semivolatile organic compounds. Environ Sci Technol 51(12):7047–7054.  https://doi.org/10.1021/acs.est.7b02319 CrossRefGoogle Scholar
  5. 5.
    Borsdorf H, Mayer T, Zarejousheghani M, Eiceman GA (2011) Recent developments in ion mobility spectrometry. Appl Spectrosc Rev 46(6):472–521CrossRefGoogle Scholar
  6. 6.
    Cumeras R, Figueras E, Davis CE, Baumbach JI, Gracia I (2015) Review on ion mobility spectrometry. Part 1: current instrumentation. Analyst 140(5):1376–1390.  https://doi.org/10.1039/C4AN01100G CrossRefGoogle Scholar
  7. 7.
    Pereira CD, Aguirre MÁ, Nóbrega JA, Hidalgo M, Canals A (2014) Aerosol generation of as and se hydrides using a new flow blurring® multiple nebulizer for sample introduction in inductively coupled plasma optical emission spectrometry. Microchem J 112:82–86.  https://doi.org/10.1016/j.microc.2013.09.006 CrossRefGoogle Scholar
  8. 8.
    Modesto-López LB, Gañán-Calvo AM (2018) Visualization and size-measurement of droplets generated by flow blurring® in a high-pressure environment. Aerosol Sci Technol 52(2):198–208.  https://doi.org/10.1080/02786826.2017.1390207 CrossRefGoogle Scholar
  9. 9.
    Liew CSM, Li X, Lee HK (2016) Miniscale liquid–liquid extraction coupled with full evaporation dynamic headspace extraction for the gas chromatography/mass spectrometric analysis of polycyclic aromatic hydrocarbons with 4000-to-14 000-fold enrichment. Anal Chem 88(18):9095–9102.  https://doi.org/10.1021/acs.analchem.6b02056 CrossRefGoogle Scholar
  10. 10.
    Liew CSM, Li X, Zhang H, Lee HK (2018) A fully automated analytical platform integrating water sampling-miniscale-liquid-liquid extraction-full evaporation dynamic headspace concentration-gas chromatography-mass spectrometry for the analysis of ultraviolet filters. Anal Chim Acta 1006:33–41.  https://doi.org/10.1016/j.aca.2017.12.035 CrossRefGoogle Scholar
  11. 11.
    Borsdorf H, Fiedler P, Mayer T (2015) The effect of humidity on gas sensing with ion mobility spectrometry. Sensor Actuators B Chem 218:184–190CrossRefGoogle Scholar
  12. 12.
    Prodhan MDH, Papadakis EN, Papadopoulou-Mourkidou E (2015) Determination of multiple pesticide residues in eggplant with liquid chromatography-mass spectrometry. Food Anal Method 8(1):229–235.  https://doi.org/10.1007/s12161-014-9898-3 CrossRefGoogle Scholar
  13. 13.
    Casida JE (2017) Pesticide interactions: mechanisms, benefits, and risks. J Agric Food Chem 65(23):4553–4561.  https://doi.org/10.1021/acs.jafc.7b01813 CrossRefGoogle Scholar
  14. 14.
    Yagur-Kroll S, Amiel E, Rosen R, Belkin S (2015) Detection of 2,4-dinitrotoluene and 2,4,6-trinitrotoluene by an Escherichia coli bioreporter: performance enhancement by directed evolution. Appl Microbiol Biot 99(17):7177–7188.  https://doi.org/10.1007/s00253-015-6607-0 CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department Monitoring and Exploration TechnologiesUFZ-Helmholtz Centre for Environmental ResearchLeipzigGermany
  2. 2.Airsense Analytics GmbHSchwerinGermany

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