Soft Tissue Special Issue: Myoepithelial Neoplasms of Soft Tissue: An Updated Review with Emphasis on Diagnostic Considerations in the Head and Neck

  • Vickie Y. JoEmail author
Special Issue: Soft Tissue


Primary myoepithelial neoplasms of soft tissue have been shown to be related to their salivary gland counterparts, with which they often share morphologic, immunophenotypic, and molecular genetic features, such as the presence of PLAG1 rearrangement in both soft tissue mixed tumor and salivary pleomorphic adenoma. However, important distinctions remain between soft tissue and salivary myoepithelial neoplasms, namely differing criteria for malignancy. This review provides an overview of the current understanding of the clinicopathologic and molecular features of soft tissue myoepithelial neoplasms, including discussion of the similarities and differences between soft tissue and salivary counterparts and relevant diagnostic issues specific to head and neck pathology practice.


Head and neck Soft tissue Myoepithelioma Myoepithelial carcinoma Mixed tumor EWSR1 PLAG1 


Compliance with Ethical Standards

Conflict of interest

Vickie Y. Jo declares that she has no conflicts of interest to the content of this article.


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© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  1. 1.Department of PathologyBrigham and Women’s Hospital and Harvard Medical SchoolBostonUSA

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