Salivary duct carcinoma (SDC) is a high-grade carcinoma with poor prognosis, especially among various salivary carcinomas. In this study, we report a rare case of SDC of the parotid gland originating from an epithelial-myoepithelial carcinoma (EMC). A 71-year-old Japanese man presented with swelling of the right parotid region and a right facial nerve paralysis for 10 months. He underwent extended total parotidectomy and chemoradiotherapy after the surgery. Histologically, a major part of the tumor was an androgen receptor (AR)-positive, human epidermal growth factor receptor 2 (HER2)-positive, gross cystic disease fluid protein-15 (GCDFP-15)-positive SDC, with a focus of a typical EMC component at the periphery of the lesion. In the transitional area of the two components, inner ductal cells of double-layered ducts showed similar morphology and immunophenotype to SDC. These findings suggest that SDC originated from the inner ductal cells of EMC. Because the tumor included an EMC as a low-grade carcinoma and an SDC as a high-grade carcinoma, we can consider our case as a dedifferentiated carcinoma as well as a hybrid tumor.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Adel K, et al. WHO classification of head and neck tumours. Lyon: IARC Press; 2017. pp. 173–5.
Seifert G, et al. Hybrid tumors of salivary glands. Definition and classification of five rare cases. Eur J Cancer B. 1996;32:251–9.
Croitoru CM, et al. Hybrid carcinomas of the salivary glands. Report of 4 cases and review of the literature. Arch Pathol Lab Med. 1999;123:698–702.
Zardawi IM. Hybrid carcinoma of the salivary gland. Histopathology. 2000;37:283–4.
Nagao T, et al. Hybrid carcinomas of the salivary glands: report of nine cases with a clinicopathologic immunohistochemical, and p53 gene alteration analysis. Mod Pathol. 2002;15:724–33.
Kainuma K, et al. Hybrid carcinoma of the parotid gland: report of a case (epithelial-myoepithelial carcinoma and salivary duct carcinoma) and review of the literature. Acta Otolaryngol. 2010;130:185–9.
Chênevert J, et al. DOG1: a novel marker of salivary acinar and intercalated duct differentiation. Mod Pathol. 2012;25:919–29.
Seethala RR, et al. New variants of epithelial-myoepithelial carcinoma: oncocytic-seba-ceous and apocrine. Arch Pathol Lab Med. 2009;133:950–9.
Seethala RR. Oncocytic and apocrine epithelial myoepithelial carcinoma: novel variants of a challenging tumor. Head Neck Pathol. 2013;7:77–84.
Gnepp DR, et al. Salivary and lacrimal glands. In: Gnepp DR, editor. Diagnostic Surgical Pathology of the Head and Neck. Philadelphia: WB Saunders Co.; 2000. pp. 325–430.
Ballestin C, et al. Combined acinic cell mucoepidermoid carcinoma of the parotid gland. Report of a case with immunohistochemical study. APMIS. 1996;104:99–102.
Chetty R, et al. Hybrid carcinomas of the salivary glands. Arch Pathol Lab Med. 2000;124:494–6.
Piana S, et al. Epstein-Barr-positive lymphoepithelial carcinoma and epi-myoepithelial cell carcinoma of the parotid gland: a hitherto unreported example of hybrid tumor. Virchows Arch. 2004;445:425–8.
Murphy JG, et al. Salivary hybrid tumor: adenoid cystic carcinoma and basal cell adenocarcinoma. Virchows Arch. 2006;448:236–8.
Atay G, et al. Hybrid carcinoma of the parotid gland: ductal carcinoma and myoepithelial carcinoma. Kulak Burun Bogaz Ihtis Derg. 2014;24:46–9.
Sabri A, et al. Hybrid tumor of the parotid gland: a case report and review of the literature. Case Rep Otolaryngol. 2015;2015:192453.
Katoh M, et al. An orderly retreat: dedifferentiation is a regulated process. Proc Natl Acad Sci USA. 2004;101:7005–10.
Gnepp DR, et al. Salivary and lacrimal glands. In: Gnepp DR, editor. Diagnostic Surgical Pathology of the Head and Neck. 2nd ed. Philadelphia: Saunders; 2009. pp. 413–562.
The authors thank all medical technologists (Osaka International Cancer Institute) for their technical assistance and Editage (http://www.editage.jp) for English language editing. No funding obtained.
Conflict of interest
The authors declare that they have no conflict of interest.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
About this article
Cite this article
Hamamoto, Y., Harada, H., Suzuki, M. et al. Salivary Duct Carcinoma of the Parotid Gland Originating from an Epithelial-Myoepithelial Carcinoma: Report of a Rare Case. Head and Neck Pathol 14, 283–289 (2020). https://doi.org/10.1007/s12105-019-01034-0
- Salivary duct carcinoma
- Parotid gland
- Epithelial-myoepithelial carcinoma