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Tongue Lumps and Bumps: Histopathological Dilemmas and Clues for Diagnosis

  • Irit AllonEmail author
  • Marilena Vered
  • Ilana Kaplan
Special Issue: Colors and Textures, a Review of Oral Mucosal Entities

Abstract

Exophytic lesions of the tongue encompass a diverse spectrum of entities. These are most commonly reactive, arising in response to local trauma but can also be neoplastic of epithelial, mesenchymal or miscellaneous origin. In most cases, the microscopic examination is likely to provide a straightforward diagnosis. However, some cases can still raise microscopic diagnostic dilemmas, such as conditions that mimic malignancies, benign tumors with overlapping features and anecdotal lesions. A series of “lumps and bumps” of the tongue are presented together with suggested clues that can assist in reaching a correct diagnosis, emphasizing the importance of the clinico-pathological correlations.

Keywords

Tongue Lumps and bumps Pseudoepitheliomatous hyperplasia Verrucous lesions Neural lesion Spindle cell tumors Adipocytic tumors Lymphoid-rich lesions 

Notes

Funding

No funding was received for this study.

Compliance with Ethical Standards

Conflict of interest

Irit Allon, Marilena Vered declares, Ilana Kaplan declares that they have no conflict of interest.

Research Involving Human Participants and/or Animals

This article does not contain any studies with human participants performed by any of the authors.

References

  1. 1.
    Brad W, Neville DD, Chi AC, Allen CM. Oral and maxillofacial pathology, 4th edn. Elsevier Health Sciences; 2015. p. 34–35, 336–338, 389–391, 473–475, 497–498, 502–503, 512–514.Google Scholar
  2. 2.
    Awadallah M, Idle M, Patel K, Kademani D. Management update of potentially premalignant oral epithelial lesions. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;125:628–36.CrossRefGoogle Scholar
  3. 3.
    Angiero F, Berenzi A, Benetti A, Rossi E, Del Sordo R, Sidoni A, Stefani M, Dessy E. Expression of p16, p53 and Ki-67 proteins in the progression of epithelial dysplasia of the oral cavity. Anticancer Res. 2008;28:2535–9.Google Scholar
  4. 4.
    Zarovnaya E, Black C. Distinguishing pseudoepitheliomatous hyperplasia from squamous cell carcinoma in mucosal biopsy specimens from the head and neck. Arch Pathol Lab Med. 2005;129:e1032-6.Google Scholar
  5. 5.
    Hosseinpour S, Mashhadiabbas F, Ahsaie MG. Diagnostic biomarkers in oral verrucous carcinoma: a systematic review. Pathol Oncol Res. 2017;23:19–32.CrossRefGoogle Scholar
  6. 6.
    Raue F, Frank-Raue K. Update on multiple endocrine neoplasia yype 2: focus on medullary thyroid carcinoma. J Endocr Soc. 2018;2:933–43.CrossRefGoogle Scholar
  7. 7.
    Rawal SY, Rawal YB. Angioleiomyoma (Vascular Leiomyoma) of the oral cavity. Head Neck Pathol. 2018;12:123–6.CrossRefGoogle Scholar
  8. 8.
    Vered M, Allon I, Buchner A, Dayan D. Clinico-pathologic correlations of myofibroblastic tumors of the oral cavity. II. Myofibroma and myofibromatosis of the oral soft tissues. J Oral Pathol Med. 2007;36:304–14.CrossRefGoogle Scholar
  9. 9.
    Fisher C. Myofibrosarcoma. Virchows Arch. 2004;445:215–23.CrossRefGoogle Scholar
  10. 10.
    Eyden B. The myofibroblast: a study of normal, reactive and neoplastic tissues, with an emphasis on ultrastructure. part 2—tumours and tumour-like lesions. J Submicrosc Cytol Pathol. 2005;37:231–96.Google Scholar
  11. 11.
    Kato MG, Erkul E, Brewer KS, Harruff EE, Nguyen SA, Day TA. Clinical features of ectomesenchymal chondromyxoid tumors: a systematic review of the literature. Oral Oncol. 2017;67:192–7.CrossRefGoogle Scholar
  12. 12.
    Dickson BC, Antonescu CR, Argyris PP, Bilodeau EA, Bullock MJ, et al. Ectomesenchymal chondromyxoid tumor: a neoplasm characterized by recurrent RREB1-MKL2 fusions. Am J Surg Pathol. 2018;42:1297–305.CrossRefGoogle Scholar
  13. 13.
    Kauzman A, Tabet JC, Stiharu TI. Hyalinizing clear cell carcinoma: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112:e26–34.CrossRefGoogle Scholar
  14. 14.
    O’Sullivan-Mejia ED, Massey HD, Faquin WC, Powers CN. Hyalinizing clear cell carcinoma: report of eight cases and a review of literature. Head Neck Pathol. 2009;3:179–85.CrossRefGoogle Scholar
  15. 15.
    Weinreb I. Translocation-associated salivary gland tumors: a review and update. Adv Anat Pathol. 2013;20:367–77.CrossRefGoogle Scholar
  16. 16.
    Skálová A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, Bishop JA, Hunt JL, Nibu KI, Rinaldo A, Vander Poorten V, Devaney KO, Steiner P, Ferlito A. The role of molecular testing in the differential diagnosis of salivary gland carcinomas. Am J Surg Pathol. 2018;42:e11–27.CrossRefGoogle Scholar
  17. 17.
    Hisaoka M. Lipoblast: morphologic features and diagnostic value. J UOEH. 2014;1:36:115–21.Google Scholar
  18. 18.
    Allon I, Aballo S, Dayan D, Vered M. Lipomatous tumors of the oral mucosa: histomorphological, histochemical and immunohistochemical features. Acta Histochem. 2011;113:803–9.CrossRefGoogle Scholar
  19. 19.
    Allon I, Vered M, Dayan D. Liposarcoma of the tongue: clinico-pathologic correlations of a possible underdiagnosed entity. Oral Oncol. 2005;41:657–65.CrossRefGoogle Scholar
  20. 20.
    Schaefer IM, Hornick JL. Diagnostic immunohistochemistry for soft tissue and bone tumors: an update. Adv Anat Pathol. 2018;25:400–12.Google Scholar
  21. 21.
    Nishio J, Iwasaki H, Nabeshima K, Kamachi Y, Naito M. Atypical lipomatous tumor with structural rearrangements involving chromosomes 3 and 8. Anticancer Res. 2014;34:3073–6.Google Scholar
  22. 22.
    Bacon CM, Du MQ, Dogan A. Mucosa-associated lymphoid tissue (MALT) lymphoma: a practical guide for pathologists. J Clin Pathol. 2007;60:361–72.CrossRefGoogle Scholar
  23. 23.
    Stephenson P, Lamey PJ, Scully C, Prime SS. Angina bullosa haemorrhagica: clinical and laboratory features in 30 patients. Oral Surg Oral Med Oral Pathol. 1987;63:560–5.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Institute of PathologyBarzilai University Medical CenterAshkelonIsrael
  2. 2.School of Health SciencesBen-Gurion University of the NegevBeer-ShebaIsrael
  3. 3.Department of Oral Pathology and Oral Medicine, The Maurice and Gabriela Goldschleger School of Dental MedicineTel Aviv UniversityTel AvivIsrael
  4. 4.Institute of PathologySheba Medical CenterRamat GanIsrael
  5. 5.Institute of PathologyRabin Medical CenterPetah-TikvaIsrael
  6. 6.Institute of PathologyTel-Aviv Sourasky Medical CenterTel-AvivIsrael

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