HPV-Related Papillary Lesions of the Oral Mucosa: A Review

  • Sasha J. BetzEmail author
Special Issue: Colors and Textures, a Review of Oral Mucosal Entities


Human papillomaviruses (HPVs) are causative of a group of clinically papillary lesions. The HPV-related lesions of the oral cavity include squamous papilloma, condyloma acuminatum, verruca vulgaris, and multifocal epithelial hyperplasia. Benign entities, such as verruciform xanthoma or giant cell fibroma, as well as malignancies, such as papillary squamous cell carcinoma and verrucous carcinoma, may be considered in the clinical and/or histologic differential diagnoses of these lesions. Mechanisms of infection, epidemiology, clinical presentations, histologic features, and differential diagnoses of the HPV-related oral pathologies are discussed. Current concepts of viral transmission, especially as pertaining to lesions in pediatric patients, and the impacts of HPV vaccination are reviewed.


Human papillomavirus Squamous papilloma Oral warts Multifocal epithelial hyperplasia Squamous cell carcinoma HPV transmission 



The opinions and assertions expressed herein are those of the author and are not to be construed as official or representing the views of the Department of the Navy or the Department of Defense.


No funding was received in association with this article.

Compliance with Ethical Standards

Conflict of interest

Sasha J. Betz declares that she has no conflict of interest.

Ethical Approval

This article does not contain any studies with human participants or animals performed by any of the authors.


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Division of Anatomic PathologyNaval Medical Center San DiegoSan DiegoUSA

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