Intraductal Carcinoma of Salivary Glands Harboring TRIM27-RET Fusion with Mixed Low Grade and Apocrine Types

  • Haiyan LuEmail author
  • Rondell P. Graham
  • Raja Seethala
  • Deborah Chute
Case Report


Intraductal carcinomas (IDCs) of salivary gland are rare neoplasms. Here, we report a case of IDCs harboring TRIM27-RET fusion with mixed low grade and apocrine types. A 79-year-old male presented with slowly-growing left parotid mass for 2.5 years. Histologically, the tumor demonstrated two distinct morphologies; a classic intercalated duct and low grade apocrine component. The intercalated duct component was positive for S100, SOX10 and vimentin, and negative for DOG-1 and HER2. The apocrine component was positive for androgen receptor (AR) and focally positive for HER2. The tumor harbored a TRIM27-RET fusion by FISH, and was negative for ETV6 and PLAG1 rearrangements. This case is unusual in that it displays two true phenotypically distinct components, which has only rarely been reported. This is the first report of intraductal carcinoma with two true phenotypically distinct components composed of low-grade and apocrine types with RET rearrangement and TRIM27-RET fusion.


Low-grade intraductal carcinomas Low grade cribriform cystadenocarcinoma RET rearrangement TRIM27 rearrangement 



No funding was received for this work from any organizations.

Compliance with Ethical Standards

Conflict of interest

All the authors have no conflict of interest to disclose.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Haiyan Lu
    • 1
    Email author
  • Rondell P. Graham
    • 2
  • Raja Seethala
    • 3
  • Deborah Chute
    • 1
  1. 1.Department of Pathology and Laboratory MedicineCleveland Clinic FoundationClevelandUSA
  2. 2.Department of Laboratory Medicine and PathologyMayo ClinicRochesterUSA
  3. 3.Department of PathologyUniversity of PittsburghPittsburghUSA

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