Non-Keratinizing Nasopharyngeal Carcinoma with Adenomatous Differentiation

  • Fredrik PeterssonEmail author
Sine qua non Clinicopathologic Correlation


A case of non-keratinizing, EBV-positive (EBER-in situ hybridization), carcinoma with adenomatous differentiation is presented. The patient is a 40 year old male with T2N2M0 disease who received standard combined chemo- and radiotherapy with complete resolution of all tumor. The tumor cells were strongly positive for low-molecular weight cytokeratins (AE1–3) and scattered cells expressed cytokeratin 20. No expression of cytokeratin 5/6, 7, p63, TTF-1, CDX2 or androgen receptor was detected. There was no evidence of recurrence or disease progression on follow-up after 19 months, which included post treatment MRI and PET–CT scans.


Nasopharynx Carcinoma Adenocarcinoma Epstein–Barr virus 


Compliance with Ethical Standards

Conflict of interest

The author has no conflict of interest.


  1. 1.
    Petersson F. Nasopharyngeal carcinoma: a review. Semin Diagn Pathol. 2015;32(1):54–73. Scholar
  2. 2.
    Petersson F, Vijayadwaja D, Loh KS, Tan KB. Reticular and myxoid non-keratinizing nasopharyngeal carcinoma: an unusual case mimicking a salivary gland carcinoma. Head Neck Pathol. 2014;8(3):364–8. Scholar
  3. 3.
    Jain D, Parkash V, Li M, Gill J, Crouch J, Howe G et al. Epstein-Barr virus RNA detection and glandular differentiation in nasopharyngeal carcinoma: report of 2 cases. Arch Pathol Lab Med. 2000;124(9):1369–72.;2.CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ. WHO classification of head and neck tumours. Lyon: IARC Press; 2017.Google Scholar
  5. 5.
    Shanmugaratnam K, Muir C. Cancer of the nasopharynx, UICC monograph series. Copenhagen: Munksgaard; 1967.Google Scholar
  6. 6.
    Yeh S. A histological classification of carcinomas of the nasopharynx with a critical review as to the existence of lymphoepitheliomas. Cancer. 1962;15:895–920.CrossRefPubMedCentralGoogle Scholar
  7. 7.
    Liang P, Chen C, Chu C, Hu Y, Chu H, Tsung Y. The histopathologic classification, biologic characteristics and histogenesis of nasopharyngeal carcinomas. Chin Med J. 1962;81:629–58.PubMedPubMedCentralGoogle Scholar
  8. 8.
    Kuo T, Tsang NM. Salivary gland type nasopharyngeal carcinoma: a histologic, immunohistochemical, and Epstein-Barr virus study of 15 cases including a psammomatous mucoepidermoid carcinoma. Am J Surg Pathol. 2001;25(1):80–6.CrossRefPubMedCentralGoogle Scholar

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of PathologyNational University Health SystemSingaporeSingapore

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