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Non-Keratinizing Nasopharyngeal Carcinoma with Adenomatous Differentiation

  • Fredrik Petersson
Sine qua non Clinicopathologic Correlation

Abstract

A case of non-keratinizing, EBV-positive (EBER-in situ hybridization), carcinoma with adenomatous differentiation is presented. The patient is a 40 year old male with T2N2M0 disease who received standard combined chemo- and radiotherapy with complete resolution of all tumor. The tumor cells were strongly positive for low-molecular weight cytokeratins (AE1–3) and scattered cells expressed cytokeratin 20. No expression of cytokeratin 5/6, 7, p63, TTF-1, CDX2 or androgen receptor was detected. There was no evidence of recurrence or disease progression on follow-up after 19 months, which included post treatment MRI and PET–CT scans.

Keywords

Nasopharynx Carcinoma Adenocarcinoma Epstein–Barr virus 

Notes

Compliance with Ethical Standards

Conflict of interest

The author has no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of PathologyNational University Health SystemSingaporeSingapore

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