Head and Neck Pathology

, Volume 13, Issue 4, pp 661–663 | Cite as

Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma

  • Kerry B. BaumannEmail author
  • Sasha J. Betz
Sine qua non Radiology-Pathology


Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is a rare entity. Patients often present with complaints of nasal fullness, obstruction, and epistaxis. It may be confused with metastatic papillary thyroid carcinoma due to its histologic similarity and overlapping immunohistochemical studies, but it is important to distinguish between the two because of differing treatment modalities and prognosis. A significant difference between the two is that despite both entities demonstrating TTF-1 positivity, TL-LGNPPA usually does not stain for thyroglobulin. TL-LGNPPA exhibits indolent growth, with no incidence of metastasis or recurrence after surgical excision.


Thyroid-like low-grade nasopharyngeal papillary carcinoma Nasopharynx TTF-1 Papillary adenocarcinoma 



I am a military service member or federal/contracted employee of the United States government. This work was prepared as part of my official duties. Title 17 U.S.C. 105 provides that ‘copyright protection under this title is not available for any work of the United States Government.’ Title 17 U.S.C. 101 defines a U.S. Government work as work prepared by a military service member or employee of the U.S. Government as part of that person’s official duties.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interests.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institution and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of retrospective case report, formal consent is not required. The tumor tissue included in the manuscript was obtained as part of the standard of care for the patient and retrospectively collected for the case report.

Informed Consent

No identifier information is included in the case report.


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Copyright information

© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply  2018

Authors and Affiliations

  1. 1.Department of Oral and Maxillofacial PathologyNaval Post Graduate Dental SchoolBethesdaUSA
  2. 2.Department of Oral and Maxillofacial PathologyNaval Medical Center San DiegoSan DiegoUSA

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