Head and Neck Pathology

, Volume 13, Issue 4, pp 686–691 | Cite as

Synchronous Parotid (Mammary Analog) Secretory Carcinoma and Acinic Cell Carcinoma: Report of a Case

  • C. MossinelliEmail author
  • C. Pigni
  • F. Sovardi
  • A. Occhini
  • L. Preda
  • M. Benazzo
  • P. Morbini
  • F. Pagella
Case Report


Mammary analogue secretory carcinoma (MASC) is a recently described low-grade salivary gland malignancy with histologic, immunohistochemical and molecular similarities to secretory carcinoma of the breast, including a specific t(12;15)(p13;q25) resulting in an ETV6–NTRK3 gene fusion. Ultrasound and magnetic resonance imaging frequently document a macrocystic structure. The main differential diagnosis of secretory carcinoma is with low grade acinic cell carcinoma (AciCC). The two can be differentiated with immunohistochemical stains for S100, mammaglobin, carbonic anhydrase VI and DOG-1; the identification of the specific translocation can help to characterize non-typical cases. We report a unique case of synchronous MASC and AciCC presenting in a parotid gland and discuss the implications of the correct identification of the two tumors.


MASC Salivary gland tumor Cystic carcinoma Parotid Acinic cell carcinoma 


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of OtolaryngologyUniversity of Pavia and Fondazione IRCCS Policlinico San MatteoPaviaItaly
  2. 2.Department of Clinical, Surgical, Diagnostic and Paediatric SciencesUniversity of PaviaPaviaItaly
  3. 3.Department of Molecular Medicine - Unit of PathologyUniversity of Pavia and Fondazione IRCCS Policlinico San MatteoPaviaItaly

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