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Primary Pleomorphic Lipoma of the Parotid Gland with Prominent Myxoid Change: Report of a Rare Case Mimicking Carcinoma Ex Pleomorphic Adenoma on Fine Needle Aspiration Cytology

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Abstract

We present a case of a primary 2.5 cm pleomorphic lipoma of the right parotid gland with prominent myxoid change which on FNA displayed features that mimicked a carcinoma or sarcoma ex pleomorphic adenoma. The patient was a 79 year old man with no oncological history or tumor elsewhere. On immunohistochemistry the neoplastic cells strongly expressed CD34. There was no expression of retinoblastoma protein, smooth muscle actin, S100-protein or cytokeratins (AE1/3 and CAM5.2). The Ki-67 proliferation index was low (< 2%). Fluorescence in situ hybridization was negative for MDM2 gene amplification.

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References

  1. Agaimy A. Fat-containing salivary gland tumors: a review. Head Neck Pathol. 2013;7:90–96 (Epub 2013 Jul 3).

    Article  Google Scholar 

  2. Chen BJ, Mariño-Enríquez A, Fletcher CD, et al. Loss of retinoblastoma protein expression in spindle cell/pleomorphic lipomas and cytogenetically related tumors: an immunohistochemical study with diagnostic implications. Am J Surg Pathol. 2012;36(8):1119–28.

    Article  Google Scholar 

  3. Michal M, Agaimy A, Contreras AL, et al. Dysplastic lipoma: a distinctive atypical lipomatous neoplasm with anisocytosis, focal nuclear atypia, p53 overexpression, and a lack of MDM2 gene amplification by FISH; a report of 66 cases demonstrating occasional multifocality and a rare association with retinoblastoma. Am J Surg Pathol. 2018;42(11):1530–40.

    Article  Google Scholar 

  4. Schoolmeester JK, Michal M, Steiner P, et al. Lipoblastoma-like tumor of the vulva: a clinicopathologic, immunohistochemical, fluorescence in situ hybridization and genomic copy number profiling study of seven cases. Mod Pathol. 2018;31(12):1862–68.

    Article  CAS  Google Scholar 

  5. Billings SD, Folpe AL. Diagnostically challenging spindle cell lipomas: a report of 34 “low-fat”and “fat-free”variants. Am J Dermatopathol. 2007;29(5):437–42.

    Article  Google Scholar 

  6. Thirumala S, Desai M, Kannan V. Diagnostic pitfalls in fine needle aspiration cytology of pleomorphic lipoma. a case report. Acta Cytol. 2000;44:653–6.

    Article  CAS  Google Scholar 

  7. Dundas KE, Wong MP, Suen KC. Two unusual benign lesions of the neck masquerading as malignancy on fine-needle aspiration cytology. Diagn Cytopathol. 1995;12:272–9.

    Article  CAS  Google Scholar 

  8. Graham CT1, Roberts AH, Padel AF. Pleomorphic lipoma of the parotid gland. J Laryngol Otol. 1998;112(2):202–3.

    Article  CAS  Google Scholar 

  9. Rosenthal LS, Garzon S, Setty S, et al. Left-sided facial mass. Spindle cell lipomas of the parotid gland. Arch Pathol Lab Med. 2006;130(6):875–6.

    PubMed  Google Scholar 

  10. Michal M, Kazakov DV, Hadravsky L, et al. Lipoblasts in spindle cell and pleomorphic lipomas: a close scrutiny. Hum Pathol. 2017;65:140–6.

    Article  CAS  Google Scholar 

  11. Creytens D, Mentzel T, Ferdinande L, et al. Atypical mitoses are present in otherwise classical pleomorphic lipoma. Hum Pathol. 2018. https://doi.org/10.1016/j.humpath.2018.04.032.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, National University Hospital, Singapore, Singapore

    Giap Hean Goh, Thomas Choudary Putti & Fredrik Petersson

  2. Department of Otolaryngology - Head and Neck Surgery (ENT), National University Hospital, Singapore, Singapore

    Raymond Ngo

  3. Institute of Pathology, University Hospital Erlangen, Friedrich Alexander University (FAU), Erlangen, Germany

    Abbas Agaimy

  4. Department of Pathology, National University Health System, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore

    Fredrik Petersson

Authors
  1. Giap Hean Goh
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  2. Thomas Choudary Putti
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  3. Raymond Ngo
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  4. Abbas Agaimy
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  5. Fredrik Petersson
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Correspondence to Fredrik Petersson.

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Goh, G.H., Putti, T.C., Ngo, R. et al. Primary Pleomorphic Lipoma of the Parotid Gland with Prominent Myxoid Change: Report of a Rare Case Mimicking Carcinoma Ex Pleomorphic Adenoma on Fine Needle Aspiration Cytology. Head and Neck Pathol 14, 246–249 (2020). https://doi.org/10.1007/s12105-018-00998-9

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  • DOI: https://doi.org/10.1007/s12105-018-00998-9

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