A Study of Immunogenicity of Intensified Hepatitis B Vaccination in Children Being Treated for Acute Lymphoblastic Leukemia

  • Sapna Nayak
  • Shreya Gupta
  • Praveen Kumar
  • Manoj Jias
  • Piali Mandal
  • Jagdish ChandraEmail author
Clinical Brief


Children with acute lymphocytic leukemia (ALL) are at an increased risk of acquiring hepatitis B infection due to repeated exposure to blood products. They have poor response to vaccination due to immunosuppressive effects of malignant disease and chemotherapy; hence necessitating vaccination with increased doses or increased amount of vaccine or both. The authors studied 44 patients (32 boys and 12 girls) given double dose hepatitis B vaccination at 0, 1 and 2 mo during induction and consolidation phase of therapy. Of the thirty patients who completed the study, only 13 (43.34%) developed protective antibody levels (titres >10 mIU/ml) measured 4 wk after the third dose. The authors conclude that with three double dose schedule of Hepatitis B vaccination, response rate is poor. Therefore, for protection from Hepatitis B infection during initial phase of therapy, there is a need to provide passive immunization.


Vaccination Hepatitis B Leukemia ALL 


Authors’ Contribution

All authors contributed equally. JC will act as guarantor for this paper.

Compliance with Ethical Standards

Conflict of Interest



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Copyright information

© Dr. K C Chaudhuri Foundation 2020

Authors and Affiliations

  • Sapna Nayak
    • 1
  • Shreya Gupta
    • 1
  • Praveen Kumar
    • 1
  • Manoj Jias
    • 2
  • Piali Mandal
    • 1
  • Jagdish Chandra
    • 1
    Email author
  1. 1.Department of PediatricsKalawati Saran Children’s Hospital, Lady Hardinge Medical College, Bangla Sahib MargNew DelhiIndia
  2. 2.Department of MicrobiologyKalawati Saran Children’s Hospital, Lady Hardinge Medical CollegeNew DelhiIndia

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