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Predictors of Mortality in Children Admitted to the Pediatric Intensive Care Unit with Acute Gastroenteritis with Severe Dehydration

  • Man Singh
  • Jhuma SankarEmail author
  • Arvind Kumar
  • U. Vijay Kumar
  • Rakesh Lodha
  • Sushil K. Kabra
Clinical Brief
  • 6 Downloads

Abstract

The objective of the present study was to identify risk factors for mortality at admission in children admitted to the Pediatric Intensive Care Unit (PICU) with acute gastroenteritis (AGE) with severe dehydration and shock. This was a retrospective chart review of all cases of AGE with severe dehydration and shock admitted to the PICU from 2012 to 2017. Children who died during hospital stay were compared with those who survived. A total of 62 children were admitted with AGE to the PICU during this period. Twenty-four children (39%) died. The following variables were found to be significantly associated with death on univariate analysis: clinical pallor (p = 0.01), thrombocytopenia (p = 0.018), elevated leucocyte count (p = 0.02), hypoalbuminemia (p = 0.02) and severe acute malnutrition (SAM) (p = 0.04). On multivariate analysis, only hypoalbuminemia {RR [95% CI: 2.6 (1.27 to 9.21)]; 0.039} and SAM {RR [95% CI: 4.9 (1.12 to 10)]; 0.045} remained statistically significant. Children admitted with severe dehydration and shock had high mortality rates. These children were a sicker subset with probable sepsis. Severe acute malnutrition and hypoalbuminemia were associated with increased risk of death in these patients.

Keywords

Diarrhea Acute gastroenteritis Shock Hypoalbuminemia Oral rehydration solution 

Notes

Authors’ Contribution

JS, RL, SKK conceptualized, designed the study and developed the protocol. MS, AK, and UVK collected the data and helped with the review of the literature and writing the manuscript. JS performed the statistical analysis and wrote the manuscript. All authors approved the final versions of the manuscript. SKK will act as guarantor for this paper.

Compliance with Ethical Standards

Conflict of Interest

None.

Supplementary material

12098_2019_3094_MOESM1_ESM.docx (15 kb)
Supplementary Table 1 (DOCX 14 kb)

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Copyright information

© Dr. K C Chaudhuri Foundation 2019

Authors and Affiliations

  1. 1.Department of PediatricsAll India Institute of Medical SciencesNew DelhiIndia

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