The Indian Journal of Pediatrics

, Volume 86, Issue 5, pp 412–416 | Cite as

Liver Involvement in Congenital Hypopituitarism

  • Derya AltayEmail author
  • Erdal Eren
  • Tanju Basarır Ozkan
  • Taner Ozgur
  • Omer Tarım
Original Article



Cholestatic jaundice in early infancy is a complex diagnostic challenge. Cholestasis caused by endocrine disease is rare and poorly recognized. The aim of this paper is to report patients with liver dysfunctions resulting from hypopituitarism.


Six patients with liver dysfunction diagnosed as hypopituitarism were studied and followed up at Uludag University Faculty of Medicine.


The median age of the patients at first presentation was 2.5 mo. Three patients were diagnosed with congenital hypopituitarism at the first visit, and the other three were diagnosed during follow-up. Serum aminotransferase levels were very high in two patients and only moderately elevated in the others. Combined adrenal, thyroid, and growth hormone deficiencies were diagnosed in two patients, while remaining 4 patients had various combinations of adrenal, thyroid, and growth hormone deficiencies. Liver function abnormalities resolved between 10 d and 2 mo follow-up after hormone replacement therapy.


Abnormal liver biochemical test results due to hormonal deficiencies in infants should be considered in the differential diagnosis by pediatricians. Hormone replacement therapy is the basis of treatment.


Cholestasis Hyperbilirubinemia Hypopituitarism 


Compliance with Ethical Standards

Conflict of Interest


Source of Funding



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Copyright information

© Dr. K C Chaudhuri Foundation 2019

Authors and Affiliations

  • Derya Altay
    • 1
    Email author
  • Erdal Eren
    • 2
  • Tanju Basarır Ozkan
    • 3
  • Taner Ozgur
    • 3
  • Omer Tarım
    • 2
  1. 1.Department of Pediatric Gastroenterology, Hepatology and NutritionErciyes University Faculty of MedicineKayseriTurkey
  2. 2.Department of Pediatric EndocrinologyUludag University Faculty of MedicineBursaTurkey
  3. 3.Department of Pediatric Gastroenterology, Hepatology and NutritionUludag University Faculty of MedicineBursaTurkey

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