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The Indian Journal of Pediatrics

, Volume 86, Supplement 1, pp 25–33 | Cite as

Menstrual Cycle and Headache in Teenagers

  • Luigi Bianchin
  • Mauro Bozzola
  • Antonio Battistella Pier
  • Sergio Bernasconi
  • Gianni Bona
  • Fabio Buzi
  • Carlo De Sanctis
  • Vincenzo De Sanctis
  • Giorgio Tonini
  • Giorgio Radetti
  • Franco Rigon
  • Egle PerissinottoEmail author
Review Article
  • 59 Downloads

Abstract

Objective

This population-based study on school-aged girls aimed to estimate the rate of peri-menstrual headache, evaluate headache pain pattern during the menstrual cycle, and verify its relationships with physical, psychosocial and life-style factors.

Methods

The students (n = 4973) fulfilled a self-administered questionnaire on demographic and behavioral characteristics, menarche, menstrual pattern and features including headache and dysmenorrhea. The prevalence of headache and the mean pain intensity score at the three menstrual cycle phases (premenstrual, menstrual, in-between period) were estimated, both overall and by gynecological year. Furthermore, the prevalence of three different patterns of headache (peri menstrual/mid-cycle/acyclic) was evaluated, together with the mean pain intensity score.

Results

The overall prevalence of headache at least once at any time during the menstrual cycle was 64.4%. At multivariable logistic analysis, gynecological age (OR 1.07; 95%CI 1.03–1.12), middle social level (1.24; 1.01–1.55, compared to high social level), physical activity (0.67; 0.51–0.89), oral contraceptive use (1.34; 1.04–1.73) and dysmenorrhea (2.30; 1.54–3.42) were significantly associated with headache. Among girls with headache, 83.4% had peri-menstrual headache (44.6% premenstrual, 38.8% menstrual), 3.5% mid-cycle headache and 13.2% acyclic headache. The gynaecological age and dysmenorrhea were significantly associated with the headache pattern (p = 0.03 and p < 0.0001, respectively).

Conclusions

This study suggests that peri-menstrual headache is highly prevalent among adolescents. In girls, the headache rate linearly raises with higher gynecological age; menses-related painful syndromes, such as headache and dysmenorrhea, are strongly interrelated. The anamnesis and monitoring of menstrual health should be mandatory when taking care of girls with headache.

Keywords

Adolescents. Menstrual headache Headache pattern Pain Gynecological age Dysmenorrhea 

Notes

Contributions

DSC: Conception and design of the study, acquisition of data, revision of the paper; DSV: Conception and design of the study, acquisition of data, interpretation of data, revision of the paper; PE: Conception of the scientific question and design of the study, analysis and interpretation of data, draft and revision of the paper; RG: Conception and design of the study, acquisition of data, interpretation of data, revision of the paper; RF: conception and design of the study, acquisition of data, interpretation of data, revision of the paper.

BL: Conception of the scientific question and design of the study, analysis and interpretation of data, draft and revision of the paper; BM: Conception and design of the study, acquisition of data, interpretation of data, revision of the paper; BPA: Conception of the scientific question, revision of the paper; BS, BG, BF and TG: Conception and design of the study, acquisition of data, interpretation of data and revision of the paper. PE will act as guarantor for this paper.

Compliance with Ethical Standards

Conflict of Interest

None.

Source of Funding

None.

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Copyright information

© Dr. K C Chaudhuri Foundation 2019

Authors and Affiliations

  • Luigi Bianchin
    • 1
  • Mauro Bozzola
    • 2
  • Antonio Battistella Pier
    • 3
  • Sergio Bernasconi
    • 4
  • Gianni Bona
    • 5
  • Fabio Buzi
    • 6
  • Carlo De Sanctis
    • 7
  • Vincenzo De Sanctis
    • 8
  • Giorgio Tonini
    • 9
  • Giorgio Radetti
    • 10
  • Franco Rigon
    • 3
  • Egle Perissinotto
    • 11
    Email author
  1. 1.Child Psychiatric UnitLocal Health and Social Care Services - ULSS 6 EuganeaPaduaItaly
  2. 2.Internal Medicine and Therapeutics, Section of Childhood and Adolescence, Foundation IRCCS San MatteoUniversity of PaviaPaviaItaly
  3. 3.Department of Woman’s and Child HealthUniversity of PaduaPaduaItaly
  4. 4.Department of Pediatrics, University of ParmaParmaItaly
  5. 5.Division of Pediatrics, Department of Mother and Child HealthAzienda Ospedaliero-Universitaria Maggiore della CaritàNovaraItaly
  6. 6.Department of Pediatrics“Carlo Poma” HospitalMantovaItaly
  7. 7.Department of Pediatric EndocrinologyOspedale Infantile Regina MargheritaTurinItaly
  8. 8.Private Accredited Hospital QuisisanaPediatric and Adolescent Outpatients ClinicFerraraItaly
  9. 9.University of TriesteTriesteItaly
  10. 10.Department of PediatricsRegional Hospital of BolzanoBolzanoItaly
  11. 11.Unit of Biostatistics, Epidemiology Public Health, Department of Cardiac, Thoracic, Vascular Science and Public HealthUniversity of PaduaPaduaItaly

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