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A Case of Juvenile Alexander Disease Presenting as Microcephaly

  • Vykuntaraju K. Gowda
  • Varunvenkat M. Srinivasan
  • Kapil Jetha
  • Maya D. Bhat
Scientific Letter

Notes

Contributions

VKG: Revised and approved the manuscript for important intellectual content and will act as guarantor of the paper;VMS: Diagnosis, management and writing the manuscript; KJ: Conducted laboratory tests and analyzed the data; MDB: Supervision of the work and revision of manuscript.

Compliance with Ethical Standards

Conflict of Interest

None.

Source of Funding

None.

References

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    Alexander WS. Progressive fibrinoid degeneration of fibrillary astrocytes associated with mental retardation in a hydrocephalic infant. Brain. 1949;72:373–81.CrossRefGoogle Scholar
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    van der Knaap MS, Salomons GS, Li R, et al. Unusual variants of Alexander’s disease. Ann Neurol. 2005;57:327–38.CrossRefGoogle Scholar
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    Gorospe JR, Naidu S, Johnson AB, et al. Molecular findings in symptomatic and pre-symptomatic Alexander disease patients. Neurology. 2002;58:1494–500.CrossRefGoogle Scholar
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    Bonthius DJ, Karacav B. Alexander disease: a novel mutation in GFAP leading to epilepsia partialis continua. J Child Neurol. 2016;31:869–72.CrossRefGoogle Scholar
  5. 5.
    Seguias L, Khan M. A young child with seizures and mild developmental delay. Pediatr Ann. 2013;42:234–7.CrossRefGoogle Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 2019

Authors and Affiliations

  1. 1.Department of Pediatric NeurologyIndira Gandhi Institute of Child HealthBangaloreIndia
  2. 2.Bangalore Child Neurology and Rehabilitation CenterBangalore 560104India
  3. 3.Department of NeuroradiologyNational Institute of Mental Health and Neurosciences (NIMHANS)BangaloreIndia

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