The Indian Journal of Pediatrics

, Volume 86, Issue 1, pp 60–69 | Cite as

Bacterial Infections of the Central Nervous System

  • Renu Suthar
  • Naveen SankhyanEmail author
Review Article


Bacterial infections of the central nervous system (CNS) continue to be an important cause of morbidity and mortality in children. The spectrum of bacterial infection of CNS includes; focal or multifocal infections like brain abscesses or subdural empyema; or more generalized or diffuse infections like pyogenic meningitis or ventriculitis. Focal and generalized infections may co-exist in an individual patient. Prompt and adequate antibiotic therapy and occasionally neurosurgical interventions are the cornerstone of effective management. The recent emergence of several multidrug-resistant bacteria poses a threat to the effective management of bacterial CNS infections. Several adjunctive anti-inflammatory and neuroprotective therapies are being tried, however; none has made a remarkable impact on the outcome. Consequently, bacterial CNS infections in children still remain a challenge to manage. In this review, authors discuss the current updates on the diagnostic and therapeutic aspects of bacterial infections of the CNS in children (post-neonatal age group).


Neuroinfections Pyomeningitis Intracranial suppuration Pyogenic brain abscess Bacterial meningitides 



RS: Reviewed the literature, wrote the manuscript; NS: Reviewed the literature, and finalized the manuscript.

Compliance with Ethical Standards

Conflict of Interest


Source of Funding



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Copyright information

© Dr. K C Chaudhuri Foundation 2018

Authors and Affiliations

  1. 1.Pediatric Neurology and Neurodevelopment Unit, Department of Pediatrics, Advanced Pediatric CentrePost Graduate Institute of Medical Education and ResearchChandigarhIndia

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