miRNA signatures in childhood sarcomas and their clinical implications

  • G. M. Viera
  • K. B. Salomao
  • G. R. de Sousa
  • M. Baroni
  • L. E. A. Delsin
  • J. A. Pezuk
  • M. S. BrassescoEmail author
Review Article


Progresses in multimodal treatments have significantly improved the outcomes for childhood cancer. Nonetheless, for about one-third of patients with Ewing sarcoma, rhabdomyosarcoma, or osteosarcoma steady remission has remained intangible. Thus, new biomarkers to improve early diagnosis and the development of precision-targeted medicine remain imperative. Over the last decade, remarkable progress has been made in the basic understanding of miRNAs function and in interpreting the contribution of their dysregulation to cancer development and progression. On this basis, this review focuses on what has been learned about the pivotal roles of miRNAs in the regulation of key genes implicated in childhood sarcomas.


miRNA Cancer Children Sarcoma Review 


Compliance with ethical standards

Conflict of interest

Nothing to declare.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

For this type of study, formal consent is not required.


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