Feasibility of a deep hyperthermia and radiotherapy programme for advanced tumors: first Spanish experience
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Hyperthermia (HT) is used to increase the temperature of the tumor-sensitizing cells to the effects of radiation/chemotherapy. We aimed to assess the feasibility, tolerability and safety of hyperthermia treatment in a Radiation Oncology Department.
Between June 2015 and June 2017, 106 patients and a total of 159 tumor lesions were included in a prospective study (EudraCT 2018-001089-40) of HT concomitant with radiotherapy (RT). Systemic treatment was accepted. HT was given twice a week, 60 min per session, during RT treatment by a regional capacitive device (HY-DEEP 600WM system) at 13.56 MHz radiofrequency.
Most lesions (138 cases, 86.8%) received all HT sessions planned. Thirteen lesions (12 patients) withdrew treatment due to grade ≥3 QMHT toxicity. All these 12 patients completed the prescribed radiotherapy and/or systemic treatment.
Regional hyperthermia is a feasible and safe technique to be used in combination with radiotherapy and systemic treatment.
KeywordsHyperthermia Radiotherapy Advanced tumors
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
Ethical approval (Research involving human participants and/or animals)
All human studies have been approved by the appropriate ethics committee and have, therefore, been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.
All the persons gave their informed consent prior to their inclusion in the study and details that might disclose the identity of the subjects under study were omitted.
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