A candidate for lung cancer treatment: arsenic trioxide

  • W. Huang
  • Y. C. ZengEmail author
Review Article


Arsenic trioxide (ATO), a highly effective drug in treating acute promyelocytic leukemia with low toxicity, demonstrates a significant effect on lung cancer. The anti-cancer mechanisms of ATO include inhibition of cancer stem-like cells, induction of apoptosis, anti-angiogenesis, sensitization of chemotherapy and radiotherapy, anti-cancer effects of hypoxia, and immunoregulation properties. In addition, some studies have reported that different lung cancers respond differently to ATO. It was concluded on numerous studies that the rational combination of administration and encapsulation of ATO have promising potentials in increasing drug efficacy and decreasing adverse drug effects. We reviewed the efficacy of ATO in the treatment of lung cancer in recent years to provide some views for further study.


Arsenic trioxide Lung cancer Anti-cancer mechanism Drug combination Encapsulation 



This work was supported by the National Natural Science Foundation of China (No. 81201803) and the Foundation of Liaoning Province Education Administration (No. LQNK201714).

Compliance with ethical standards

Conflict of interest

The authors declare that there is no conflict of interest.

Ethical approval

The manuscript does not report clinical or patient data acquired by any of the authors.

Research involving human participants and/or animals

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

The manuscript does not report clinical or patient data acquired by any of the authors.


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Copyright information

© Federación de Sociedades Españolas de Oncología (FESEO) 2019

Authors and Affiliations

  1. 1.Department of Medical OncologyShengjing Hospital of China Medical UniversityShenyangChina

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