Clinical and Translational Oncology

, Volume 20, Issue 11, pp 1460–1466 | Cite as

Radiotherapy volume delineation using 18F-FDG-PET/CT modifies gross node volume in patients with oesophageal cancer

  • E. Jimenez-JimenezEmail author
  • P. Mateos
  • N. Aymar
  • R. Roncero
  • I. Ortiz
  • M. Gimenez
  • J. Pardo
  • J. Salinas
  • S. Sabater
Research Article



Evidence supporting the use of 18F-FDG-PET/CT in the segmentation process of oesophageal cancer for radiotherapy planning is limited. Our aim was to compare the volumes and tumour lengths defined by fused PET/CT vs. CT simulation.

Materials and methods

Twenty-nine patients were analyzed. All patients underwent a single PET/CT simulation scan. Two separate GTVs were defined: one based on CT data alone and another based on fused PET/CT data. Volume sizes for both data sets were compared and the spatial overlap was assessed by the Dice similarity coefficient (DSC).


The gross tumour volume (GTVtumour) and maximum tumour diameter were greater by PET/CT, and length of primary tumour was greater by CT, but differences were not statistically significant. However, the gross node volume (GTVnode) was significantly greater by PET/CT. The DSC analysis showed excellent agreement for GTVtumour, 0.72, but was very low for GTVnode, 0.25.


Our study shows that the volume definition by PET/CT and CT data differs. CT simulation, without taking into account PET/CT information, might leave cancer-involved nodes out of the radiotherapy-delineated volumes.


18F-FDG-PET/CT Delineation Oesophageal Radiotherapy 


Compliance with ethical standards

Conflict of interest

No conflict of interest of any author.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutitional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

As this study is retrospective study, formal content is not required.


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Copyright information

© Federación de Sociedades Españolas de Oncología (FESEO) 2018

Authors and Affiliations

  1. 1.Radiation Oncology DepartmentSt. Lucia University General HospitalCartagenaSpain
  2. 2.Medical Physics DepartmentClinica IMQ ZorrotzaurreBilbaoSpain
  3. 3.Radiation Oncology DepartmentHospital Universitari Son EspasesPalma de MallorcaSpain
  4. 4.Nuclear Medicine DepartmentHospital Universitari Son EspasesPalma de MallorcaSpain
  5. 5.Radiation Oncology DepartmentComplejo Hospitalario Universitario de AlbaceteAlbaceteSpain

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