Clinical and Translational Oncology

, Volume 20, Issue 11, pp 1416–1421 | Cite as

Are endometrial cancer radiotherapy results age related?

  • Á. RovirosaEmail author
  • K. S. Cortés
  • C. Ascaso
  • A. Glickman
  • S. Valdés
  • A. Herreros
  • C. Camacho
  • J. Sánchez
  • Y. Zhang
  • Y. Li
  • S. Sabater
  • M. Arenas
  • A. Torne
Research Article



To analyze the impact of age on radiotherapy results based on cancer-specific survival (CSS), vaginal-cuff relapses (VCR) and complications analysis in 438 patients with endometrial carcinoma (EC) receiving postoperative radiotherapy (PRT) divided into three age groups for analysis.

Materials and methods

From 2003 to 2015, 438 patients with EC were treated with PRT and divided into three age groups: Group-1: 202 patients < 65 years; Group-2: 210 patients ≥ 65 and < 80 years; Group-3: 26 patients ≥ 80 years. Vaginal toxicity was assessed using the objective LENT-SOMA criteria and RTOG scores were recorded for the rectum, bladder, and small bowel. Statistics: Chi square and Student’s t tests, Kaplan–Meier survival study for analysis of CSS.


The mean follow-up was 5.6 years in Group-1, 5.6 years in Group-2 and 6.3 years in Group-3 (p = 0.38). No differences were found among the groups in distribution of stage, grade, myometrial invasion, Type 1 vs. 2 EC and VLSI (p = 0.97, p = 0.52, p = 0.35, p = 0.48, p = 0.76, respectively). There were no differences in rectal, bladder and vagina late toxicity (p = 0.46, p = 0.17, p = 0.75, respectively). A better CSS at 5 years was found in Group-1 (p = 0.006), and significant differences were found in late severe small bowel toxicity in Group-3 (p = 0.005). VCR was increased in Group-3 (p = 0.017).


Patients ≥ 65 years had a worse outcome in comparison to younger patients. Late vaginal, rectal and bladder toxicities were similar in the three groups, although an increase of severe late small bowel toxicity led to IMRT in patients ≥ 80 years. Further larger studies are needed including quality of life analysis in patients ≥ 80 years.


Radiotherapy results Toxicity Age Endometrial carcinoma 



This study was supported by a grant from the Spanish Association Against Cancer (AECC) Foundation (PS14152506ROVI).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study has been approved by the appropriate ethics committee and it has therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Federación de Sociedades Españolas de Oncología (FESEO) 2018

Authors and Affiliations

  1. 1.Radiation Oncology DepartmentHospital Clínic UniversitariBarcelonaSpain
  2. 2.Gynecological Cancer UnitHospital Clínic UniversitariBarcelonaSpain
  3. 3.Health Department, Faculty of MedicineUniversity of BarcelonaBarcelonaSpain
  4. 4.Economics DepartmentHospital Clinic UniversitariBarcelonaSpain
  5. 5.Fonaments Clinics, Faculty of MedicineUniversity of BarcelonaBarcelonaSpain
  6. 6.Radiation Oncology DepartmentHospital General de AlbaceteAlbaceteSpain
  7. 7.Radiation Oncology DepartmentHospital Sant Joan de ReusReusSpain

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